RNA interference with one of the eight Caenorhabditis elegans linker histone genes triggers desilencing of a repetitive transgene and developmental defects in the hermaphrodite germ line. These characteristics are similar to the phenotype of the C. elegans Polycomb group genes mes-2, mes-3, mes-4, and mes-6 (M. A. Jedrusik and E. Schulze, Development 128:1069-1080, 2001; I. Korf, Y. Fan, and S....

BACKGROUND Risk for developing metabolic syndrome (MeS) after delivery is high among women with gestational diabetes mellitus (GDM), but little is known about development of MeS among women with risk factors for GDM during pregnancy. In the present study, we studied the prevalence of MeS 7 years postpartum among women with GDM risk factors during pregnancy, women with early GDM diagnosis and wo...

Manufacturing execution system (MES) is a computer application system that integrates all relevant real-time information along every step in a manufacturing process. MES is essential for manufacturers for gathering real-time production line information, supporting manufacturing decision making and increasing manufacturing efficiency. MES is a must for operation control and lot tracking in the s...

Glioblastoma is a highly lethal cancer for which novel therapeutics are urgently needed. Two distinct subtypes of glioblastoma stem-like cells (GSCs) were recently identified: mesenchymal (MES) and proneural (PN). To identify mechanisms to target the more aggressive MES GSCs, we combined transcriptomic expression analysis and kinome-wide short hairpin RNA screening of MES and PN GSCs. In compar...

Hedgehog (Hh) signaling emerges as a potential pathway contributing to fat formation during postnatal development. In this report, we found that Patched 1 (Ptc1), a negative regulator of Hh signaling, was expressed in the epididymal fat pad of adult mice. Reduced total white fat mass and epididymal adipocyte cell size were observed in naturally occurring spontaneous mesenchymal dysplasia (mes) ...

The comprehensive o i l log i n t e r p r e t a t i o n is a procedure of numerical ca l cu la t i on and l o g i c a l (or p l aus ib l e ) in fe rence. In other words, the resu l t s of p re l im ina ry inference w i l l provide a basis f o r the choice of parameters of ca l cu l a t i on formula, and then the r e s u l t s of numerical c a l c u l a t i o n w i l l be used as evidences f o r...

So it’s no surprise that many manufacturers are incubating or executing global manufacturing execution system (MES) programs as part of their manufacturing strategies. MES implementations are challenging enough, but global MES programs involve even more complexities (see Figure 1). Typical MES challenges include selecting a best-fit MES system aligned with the company’s IT vision; choosing the ...

Autostereograms--commonly known as Magic Eye stereograms (MESs)--are two-dimensional images that support stereoscopic depth perception given an appropriate crossing or uncrossing of the eyes. We find that self-reported MES skill is highly predictive of stereoacuity as measured by a standard clinical test (r142 = 0.45, p < 0.0001; TNO test). Indeed, in our sample of 194 individuals, those who re...

Recent RNA interference (RNAi) studies have identified many host proteins that modulate virus infection, but small interfering RNA 'off-target' effects and the use of transformed cell lines limit their conclusiveness. As murine embryonic stem (mES) cells can be genetically modified and resources exist where many and eventually all known mouse genes are insertionally inactivated, it was reasoned...