The present investigation has been undertaken to evaluate role of Wheat grass extract in modifying mercury-induced biochemical alterations in albino rats. Mercuric chloride 5 mg/kg body weight i.p. was given on 11, 13 & 15th day of the experiment. Wheat grass extract (400 mg/kg) and Quercetin (10 mg/kg) were administered 10 days before mercuric chloride administration and continued up to 30 day...

The primary aim of the present study was to evaluate the effects of different means of depleting glutathione (GSH) in the kidneys and liver on the renal and hepatic accumulation and disposition of a nontoxic dose of inorganic mercury. Renal and hepatic disposition of mercury were evaluated 1 hr after the intravenous administration of a 0.5 mumol/kg dose of mercuric chloride in control rats and ...

THE LOSS OF MERCURY due to volatilization and incomplete removal of oxidizing agents which destroy dithizone are among the major problems in determining mercury in urine. This paper describes a method by which these difficulties are reduced to a minimum. In actual use, this method has been found efficient in screening large numbers of workers exposed to a mercury hazard. Most methods require a ...

Earlier, we reported that mercury, the environmental risk factor for cardiovascular diseases, activates vascular endothelial cell (EC) phospholipase D (PLD). Here, we report the novel and significant finding that calcium and calmodulin regulated mercury-induced PLD activation in bovine pulmonary artery ECs (BPAECs). Mercury (mercury chloride, 25 microM; thimerosal, 25 microM; methylmercury, 10 ...

The effect of selenite administered at various time intervals after mercury treatment on the toxicity and renal content of mercuric mercury in mice was studied. A marked protective effect of selenite on growth depression and renal lesions caused by mercuric chloride was observed in mice receiving mercury and selenite simultaneously. However, growth depression was not protected by post administr...

Stimulation with heavy metals is known to induce calcium (Ca(2+)) mobilization in many cell types. Interference with the measurement of intracellular Ca(2+) concentration by the heavy metals in cells loaded with Ca(2+) indicator fura-2 is an ongoing problem. In this study, we analyzed the effect of heavy metals on the fura-2 fluorescence ratio in human SH-SY5Y neuroblastoma cells by using TPEN,...

Effect of mercury on blood and its components of fish Labeo rohita was carried out in this study. The LC50 dose of 57.074 mg/L and mercuric chloride exposure for 96 h resulted in significant changes in the physico-chemical properties such as hemoglobin, osmotic fragility and blood cell counts. Further, mercury exposure also caused a considerable reduction in the sulf-hydryl group of glutathione...

The apical membrane is an important site of mercury toxicity in shark rectal gland tubular cells. We compared the effects of mercury and other thiol-reacting agents on shark CFTR (sCFTR) and human CFTR (hCFTR) chloride channels using two-electrode voltage clamping of cRNA microinjected Xenopus laevis oocytes. Chloride conductance was stimulated by perfusing with 10 microM forskolin (FOR) and 1 ...