نتایج جستجو برای: mercapto pyrimidine

تعداد نتایج: 10829  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2010
Minoru Uchiyama Thomas Fischer Juergen Mueller Minoru Oguchi Naotoshi Yamamura Hiroko Koda Haruo Iwabuchi Takashi Izumi

The metabolism of [(14)C]pioglitazone was studied in vitro in incubations with freshly isolated human, rat, and monkey hepatocytes. Radioactivity detection high-performance liquid chromatography analysis of incubation extracts showed the detection of 13 metabolites (M1-M13) formed in incubations with human hepatocytes. An identical set of metabolites (M1-M13) was also detected in monkey hepatoc...

In this research, the interaction of pyrimidine molecule with pristine B12N12 nanocluster is studied in different phases to understand the effect of environment on the electronic properties of the designated adsorption complexes. To this end, the pyrimidine adsorption over B12N12 in the gas phase and water medium is investigated using density functional theory (DFT) at the B97D/6-31+G(d,p) leve...

Journal: :Journal of Advances in Agriculture 2023

In field conditions, the effect of plant growth regulators Ivin (N-oxide-2,6-dimethylpyridine), Methyur (sodium salt 6-methyl-2-mercapto-4-hydroxypyrimidine), Kamethur (potassium 6-methyl-2-mercapto-4-hydroxypyrimidine) on and productivity sunflower (Helianthus annuus L.) variety Bastion was studied. The growth-regulating activity Ivin, compared with auxin IAA (1H-Indol-3-yl)acetic acid). It fo...

2010
Changhai Lu Wen Zhong

Novel propargyl-ended heterobifunctional poly(ethylene glycol) (PEG) derivatives with hydroxyl, carboxyl, mercapto or hydrazide end groups were synthesized with simplicity yet high efficiency. PEG (Mw = 3500 Da) with an α-hydroxyl group and an ω-carboxyl was used as the starting polymer. The carboxyl group of the bifunctional PEG was modified into a propargyl, then carboxyl, mercapto or hydrazi...

Journal: :Molecules 2007
Jian-yu Jin Li-xue Zhang An-jiang Zhang Xin-Xiang Lei Jiang-Hai Zhu

To discover new 1,2,4-triazole derivatives which may possess significant biological activities, we synthesized a series of novel 6-aryl-3-(D-galactopentitol-1-yl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines and 4-(arylmethylidene)amino-5-(D-galactopentitol-1-yl)-3-mercapto-4H-1,2,4-triazoles from 4-amino-3-(D-galactopentitol-1-yl)-5-mercapto-1,2,4-triazole. All the title compounds were characte...

Journal: :Physical chemistry chemical physics : PCCP 2012
Fan Gao Erdong Yao Wei Wang Hao Chen Yuguo Ma

We have developed an absorption spectrum based molecular ruler that measures the distance between two mercapto groups. The conformation of the molecular rulers changes with the distance, which induces an absorption spectrum change. DFT calculation has been carried out to elucidate the relation between the molecular conformation and the absorption spectrum. With this simple method, we can estima...

Journal: :Acta chimica Slovenica 2015
Raluca Pop Maria Ilici Mihaiela Andoni Vasile N Bercean Cornelia Muntean Monica M Venter Ilie Julean

The acidity constants Ka1 and Ka2 of 2-(5-mercapto-1,3,4-thiadiazol-2-ylthio)acetic acid have been determined both by experimental and theoretical methods. pKa computations at B3LYP/6-311+G(d,p) level of theory were carried out for the two tautomeric forms, thiol and thione, of the above-mentioned acid. Comparisons between the experimental and theoretical values led to the establishing of the m...

Journal: : 2021

A series of substituted chalcones and pyrimidine derivatives on their base was synthesized. Obtained compounds were tested for antimicrobial activity ability to increase known substances. Pyrimidine products shown good against Staphylococcus aureus Candida tropicalis. These also could modified polyguanidines aureus.

Journal: :the iranian journal of pharmaceutical research 0
nan jiang college of pharmacy, yanbian university, no. 977, park road, yanji, jilin, 133002, china. xian-qing deng college of pharmacy, yanbian university, no. 977, park road, yanji, jilin, 133002, china. fu-nan li department of pharmacy, medical college of xiamen university, no. 168, daxue rd, xiamen, fujian, 361005, china. zhe-shan quan college of pharmacy, yanbian university, no. 977, park road, yanji, jilin, 133002, china.

considerable interest has been focused on the triazole structure, which has been known to possess a broad spectrum of biological activities such as antitumor, anti-inflammatory, antimicrobial, antiviral, and anticonvulsant activities. before this, several heterocyclic compounds containing triazole were synthesized that had shown considerable anticonvulsant activity. as part of our continuous re...

T3P/DMSO is shown to be an effective and mild reagent for the one-pot synthesis of furo[2,3-d]pyrimidine-2,4(1H,3H)-diones from a variety of alcohols. Alcohols are oxidized in situ to aldehydes under mild conditions, which undergo a three-component reaction with N,N'-dimethylbarbituric acid and various isocyanides to afford furo[2,3-d]pyrimidine-2,4(1H,3H)-diones in good yields.

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