Treatment strategies for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are evolving. Cyclophosphamide (CYC) plus corticosteroids (CSs) is the mainstay of therapy for generalized, multisystemic AAV. Historically, the combination of CYC plus CS was used for a minimum of 12 months, but concern about late toxicities associated with CYC has led to novel treatment approaches...

let $g$ be a group and $x in g$‎. ‎the cyclicizer of $x$ is defined to be the subset $cyc(x)=lbrace y in g mid langle x‎, ‎yrangle ; {rm is ; cyclic} rbrace$‎. ‎$g$ is said to be a tidy group if $cyc(x)$ is a subgroup for all $x in g$‎. ‎we call $g$ to be a c-tidy group if $cyc(x)$ is a cyclic subgroup for all $x in g setminus k(g)$‎, ‎where $k(g)$ is the intersection of all the cyclicizers in ...

Despite the development of new modalities, cyclophosphamide (CYC) remains the preferred initial treatment for severe proliferative lupus nephritis. Controversies continue about the best route, dosage, and duration of CYC treatment. For recalcitrant disease, new immunosuppressive and immunomodulating agents, immunoablative high dose CYC, nucleoside analogues, apheresis, and the biological respon...

Background/Aims: Clinical methods to predict allograft function soon after kidney transplantation are ineffective. Methods: We analyzed urine cystatin C (CyC) in a prospective multicenter observational cohort study of deceaseddonor kidney transplants to determine its peritransplant excretion pattern, utility for predicting delayed graft function (DGF) and association with 3-month graft function...

Cyc, a massive project to create a knowledge base spanning all human consensus knowledge, is discussed. The project will require the development of a new logic language for expressing knowledge before sets of procedures can be created and the knowledge base itself built. Cyc programmers developed CycL, a unique representation language and inference engine. Inferencing in Cyc at the heuristic le...

In this study, acesulfame (ACE), saccharin (SAC) and cyclamate (CYC) were found in all paired urine and blood samples collected from healthy adults, with mean values of 4070, 918 and 628 ng mL(-1), respectively, in urine and 9.03, 20.4 and 0.72 ng mL(-1), respectively, in blood. SAC (mean: 84.4 ng g(-1)) and CYC (4.29 ng g(-1)) were detectable in all liver samples collected from liver cancer pa...

Exercise is now considered an important component of management in chronic heart failure (CHF), but little is known about central hemodynamic changes that occur during different exercise modalities in these patients. Seventeen patients (ejection fraction 25 +/- 2%) undertook brachial artery and right heart catheterization and oxygen consumption assessment at rest, during submaximal and peak cyc...

Using a computational approach, we have identified 49 cytochrome c (cyc) pseudogenes in the human genome. Analysis of these provides a detailed description of the molecular evolution of the cyc gene. Almost all of the pseudogenes are full-length, and we have concluded that they mostly originated from independent retrotransposition events (i.e. they are processed). Based on phylogenetic analysis...

This is the final report on the assessment of Cyc for natural language processing applications. The work reported here was carried out by the authors at CRL, NMSU under collaboration with both the Department of Defense and Cycorp, Inc. The primary motivation of this relatively small-scale exercise was to arrive at an independent assessment of the utility of Cyc’s knowledge and inference capabil...