Proper segregation of chromosomes in meiosis is essential to prevent miscarriages and birth defects. This requires that sister chromatids maintain cohesion at the centromere as cohesion is released on the chromatid arms when the homologs segregate at anaphase I. The Shugoshin proteins preserve centromere cohesion by protecting the cohesin complex from cleavage, and this has been shown in yeasts...

This thesis presents several module systems, in particular Mei and DMei, designed for mechanized mathematics systems. Mei is a λ-calculus style module system that supports higher-order functors in a natural way. The semantics of functor application is based on substitution. A novel coercion mechanism integrates a parameter passing mechanism based on theory interpretations with simple λ-calculus...

The objective of this post-hoc analysis was to investigate the relationship between motivation/energy and functional impairment in patients with major depressive disorder (MDD). Data were taken from a phase 3 trial of levomilnacipran extended-release (ER) in adults with MDD (NCT01034462; N=429) that used the 18-item Motivation and Energy Inventory (MEI) to assess motivation/energy. Two subgroup...

The Measured Equation of Invariance (MEI) method has received considerable attention recently. Unlike more traditional numerical techniques, MEI solutions are obtained by inversion of a relatively small and sparse matrix. Therefore, the MEI method can potentially provide a solution much more quickly than other techniques. To date, the MEI method has been applied primarily to discrete objects. I...

This article describes the development and initial validation of the Multicultural Environmental Inventory (MEI). The MEI is an instrument designed to measure an individual's perceptions about the degree to which graduate counseling programs address multicultural issues within curriculum, supervision, climate, and research. This investigation was conducted using the data from 208 students and f...

Meiotic chromosome segregation occurs in Drosophila oocytes on an acentrosomal spindle, which raises interesting questions regarding spindle assembly and function. One is how to organize a bipolar spindle without microtubule organizing centers at the poles. Another question is how to orient the chromosomes without kinetochore capture of microtubules that grow from the poles. We have characteriz...

In meiosis, a physical attachment, or cohesion, between the centromeres of the sister chromatids is retained until their separation at anaphase II. This cohesion is essential for ensuring accurate segregation of the sister chromatids in meiosis II and avoiding aneuploidy, a condition that can lead to prenatal lethality or birth defects. The Drosophila MEI-S332 protein localizes to centromeres w...

The summertime mei-yu–baiu rainband over East Asia displays considerable interannual variability. A singular value decomposition (SVD) analysis for interannual variability reveals that precipitation anomalies over the mei-yu–baiu region are accompanied by in situ anomalies of midtropospheric horizontal temperature advection. Anomalous warm (cool) advection causes increased (decreased) mei-yu–ba...

Myoclonic epilepsy in infancy (MEI) is a primary generalized epilepsy. According to the literature, the outcome of MEI is usually benign. Here we report a patient who developed myoclonic astatic epilepsy at age four, having been seizure free without antiepileptic drug treatment for 2 years after his recovery from MEI. At age four, a video-EEG-recording showed frequent head nodding (atonic seizu...

In adult stem cell lineages, progenitor cells commonly undergo mitotic transit amplifying (TA) divisions before terminal differentiation, allowing production of many differentiated progeny per stem cell division. Mechanisms that limit TA divisions and trigger the switch to differentiation may protect against cancer by preventing accumulation of oncogenic mutations in the proliferating populatio...