Functional magnetic resonance imaging has demonstrated reorganization of memory encoding networks within the temporal lobe in temporal lobe epilepsy, but little is known of the extra-temporal networks in these patients. We investigated the temporal and extra-temporal reorganization of memory encoding networks in refractory temporal lobe epilepsy and the neural correlates of successful subsequen...

Functional magnetic resonance imaging has demonstrated reorganization of memory encoding networks within the temporal lobe in temporal lobe epilepsy, but little is known of the extra-temporal networks in these patients. We investigated the temporal and extra-temporal reorganization of memory encoding networks in refractory temporal lobe epilepsy and the neural correlates of successful subsequen...

The MR examination of medial temporal structures has recently been pushed to the limits of current technology, with some hope of uncovering the secrets of intractable epilepsy. The specific MR imaging features of one important source of seizures, mesial temporal sclerosis, have been well described. These include a small hippocampus with abnormal signal on T2-weighted scans, but many other findi...

Background. Mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) constitutes a distinct clinical syndrome with variable pathogenesis. Extrahippocampal regions may be affected in MTLE/HS, association with cortical dysplasia is common and temporal polar cortex is frequently involved in seizure onset. Patients with dual pathology may have favourable outcome from the surgery provide...

PURPOSE To identify the extent of hippocampal sclerosis in temporal lobe epilepsy with fast spin-echo MR and correlate it with histopathologic findings and surgical outcome. METHODS MR images of 30 patients with temporal lobe epilepsy and pathologically proved hippocampal sclerosis and 30 control subjects were obtained using a fast spin-echo technique with 4000/100/4 (repetition time/echo tim...

Sir, We read with interest the study of Coras et al. (2014) reporting the absence of verbal anterograde episodic memory (AEM) impairment in patients with mesial temporal lobe epilepsy (MTLE) with a hippocampal sclerosis ILAE type 2 classification (HS ILAE 2, i.e. CA1 predominant cell loss). This finding may provide an anatomical basis for the dissociation of anterograde/long-term episodic memor...

BACKGROUND AND PURPOSE Unilateral mesial temporal lobe epilepsy and hippocampal sclerosis have structural and functional abnormalities in the mesial temporal regions. To gain insight into the pathophysiology of the epileptic network in mesial temporal lobe epilepsy with hippocampal sclerosis, we aimed to clarify the relationships between hippocampal atrophy and the altered connection between th...

BACKGROUND AND PURPOSE Although most studies on epilepsy have focused on the epileptogenic zone, epilepsy is a system-level disease characterized by aberrant neuronal synchronization among groups of neurons. Increasingly, studies have indicated that mesial temporal lobe epilepsy may be a network-level disease; however, few investigations have examined resting-state functional connectivity of th...

complex partial seizures since childhood. The seizures, which featured au tomatisms and dystonic posturing, had started following a febrile illness with a prolonged seizure when he was four years of age. Unsuccessful control of seizures using multiple an tiepileptic drugs resulted in weekly seizures, rendering him unable to drive. Neuroimaging showed gliosis and atrophy of the right hippocampus...