Meckel diverticulum is the most common congenital defect of the gastrointestinal tract. It can be asymptomatic or mimic appendicitis and may be complicated by bleeding, diverticulitis, obstruction, and, rarely, neoplasia. We report the first case of extranodal marginal zone lymphoma occupying a Meckel diverticulum. A 44-year-old man with history of colonic diverticulitis presented to the emerge...

BACKGROUND Ectopic production of adrenocorticotropic hormone (ACTH) by neuroendocrine tumours (NET) is a rare condition, occult presentations often hampering the diagnosis. Although NET are relatively frequent in the ileon and Meckel diverticulum, we describe the first Cushing's syndrome due to ectopic adrenocorticotropic syndrome (CS-EAS) arising from a Meckel diverticulum. CASE PRESENTATION...

Meckel syndrome (MKS) is a lethal, autosomal recessive condition characterised by an occipital meningoencephalocele, enlarged kidneys with multicystic dysplasia, fibrotic changes of the liver in the portal area with ductal proliferation, and postaxial polydactyly. Recently, a MKS gene has been mapped to chromosome 17q21-q24 in Finnish families, with no evidence of locus heterogeneity in this po...

Meckel-Gruber syndrome is a rare lethal autosomal recessive condition which was first described by Johann Friedrich Meckel in 1822 and GB Gruber in 1934. More than 200 cases have been reported worldwide with an incidence ranging from 1:13,250 to 1:140,000 live births. A 21-year-old female with G3 A2 L0, presented with twin pregnancy with history of previous two anencephalic pregnancies. The pre...

The primary cilium originates from the mother centriole and participates in critical functions during organogenesis. Defects in cilia biogenesis or function lead to pleiotropic phenotypes. Mutations in centrosome-cilia gene CC2D2A result in Meckel and Joubert syndromes. Here we generate a Cc2d2a(-/-) mouse that recapitulates features of Meckel syndrome including embryonic lethality and multiorg...

Giới thiệu: Túi thừa Meckel là dị tật bẩm sinh của đường tiêu hóa với tỷ lệ khoảng 0,14 – 4,5%, hầu hết không có triệu chứng và chỉ được phát hiện tình cờ. Thủng túi do vật một trong những biến rất hiếm gặp. Trình bày ca bệnh: Bệnh nhân (BN) na2m 35 tuổi vào viện biểu đau bụng cấp vùng hố chậu phải. Chụp cắt lớp vi tính ổ thấy hình ảnh nghi đâm thủng ruột. Tổn thương mổ hoại tử, xương cá gây vi...

Perforation of a Meckel diverticulum (MD) is a rare complication that can often mimic appendicitis. This case report identifies a child who presented to our Emergency Department (ED) with right lower quadrant abdominal pain, free fluid and air in the abdomen and pelvis, and inflammatory changes visualized on Ultrasonography (US) and computer tomography (CT) scan. In our patient, ruptured append...

An 18-year-old young man with no medical history presented at the emergency department with nausea, vomiting and pain in the right iliac fossa and the periumbilical region. Blood analysis was normal except for an elevated C-reactive protein (CRP) of 64 mg/L. High frequency gray-scale sonogram was performed and showed a normal presentation of the appendix. A tubular hypo-echogenic structure (len...