Dynamic processes modify bone micro-structure to adapt to external loading and avoid mechanical failure. Age-related cortical bone loss is thought to occur because of increased endocortical resorption and reduced periosteal formation. Differences in the (re)modeling response to loading on both surfaces, however, are poorly understood. Combining in-vivo tibial loading, in-vivo micro-tomography a...

The mechanisms underlying the development of painful and nonpainful neuropathy associated with diabetes mellitus are unclear. We have obtained microneurographic recordings from unmyelinated fibers in eight patients with diabetes mellitus, five with painful neuropathy, and three with neuropathy without pain. All eight patients had large-fiber neuropathy, and seven patients had pathological therm...

Atherosclerosis preferentially occurs in arterial regions exposed to disturbed flow, in part, due to alterations in gene expression. MicroRNAs (miRNAs) are small, noncoding genes that post-transcriptionally regulate gene expression by targeting messenger RNA transcripts. Emerging evidence indicates that alteration of flow conditions regulate expression of miRNAs in endothelial cells both in vit...

Gastrointestinal (GI) motility disorders such as irritable bowel syndrome (IBS) can occur when coordinated smooth muscle contractility is disrupted. Potassium (K+) channels regulate GI smooth muscle tone and are key to GI tract relaxation, but their molecular and functional phenotypes are poorly described. Here we define the expression and functional roles of mechano-gated K2P channels in mouse...

Magnetic NPs grafted via mechano-ATRP served as a powerful agent for enhancing performance and stability of magnetorheological suspensions.

The recycling of sodium borohydride poses a huge challenge to the drive towards hydrogen economy. Currently, mechano-chemical, thermo-chemical and electrochemical are only reported methods metaborate into borohydride. Much attention has been devoted mechano-chemical reduction, but little focus methods. This review describes behaviour (BH4−) (BO2−) anions in alkaline solutions. BH4− is stabilize...

From humble beginnings, cardiac mechanoelectric transduction or feedback has come of age. The last editorial board (Editor-in-Chief, David Hearse, and concerning the Focussed Issue particularly Associate Editor Michael Shattock) facilitated growth by encouraging the Issue. The present board (Editor-in-Chief, Michiel Janse, and concerning this focussed publication, Associate Editor Tobias Opthof...

See article by Nanthakumar et al. [6] (pages 303 –309) perimental animals. Human studies addressing MEF also in this issue. have focussed on unphysiological conditions, such as compression /decompression of the left ventricle during cardiopulmonary bypass surgery [3], transient aortic occlu