We studied regional blood flow (QR) using radiolabeled microspheres and measured hemodynamic variables in 20 anesthetized dogs in normal sinus rhythm and during ventricular fibrillation treated with cardiopulmonary resuscitation (CPR). Nonsimultaneous compression and ventilation CPR (NSCV-CPR) was performed in seven dogs with a pneumatic piston that gave 50 chest compressions/min with an open a...

QUESTIONS UNDER STUDY After years of advocating ABC (Airway-Breathing-Circulation), current guidelines of cardiopulmonary resuscitation (CPR) recommend CAB (Circulation-Airway-Breathing). This trial compared ABC with CAB as initial approach to CPR from the arrival of rescuers until the completion of the first resuscitation cycle. METHODS 108 teams, consisting of two physicians each, were rand...

OBJECTIVE We sought to determine whether the use of currently issued gowns delays initiation of chest compressions and ventilations during cardiopulmonary resuscitation and whether simple gown modifications can reduce this delay. METHODS Firefighter defibrillation instructors were allocated into pairs and videotaped while performing standardized cardiac arrest scenarios. Three scenarios were ...

OBJECTIVE To investigate the effect of different ventilation settings on hemodynamic stability in severe controlled hemorrhagic shock. DESIGN Prospective, randomized, controlled animal study. SETTING Research laboratory in a university hospital. SUBJECTS Approximately 35-45 kg domestic pigs. INTERVENTIONS Twenty-four domestic pigs were bled 45 mL/kg (estimated 65% of their calculated bl...

It is not known whether the high total work of breathing (WOB) in exercising women is higher due to differences in the resistive or elastic WOB. Accordingly, the purpose of this study was to determine which factors contribute to the higher total WOB during exercise in women. We performed a comprehensive analysis of previous data from 16 endurance-trained subjects (8 men and 8 women) that underw...

Objective: A significant percent of survivors from cardiac arrest and resuscitation suffer permanent brain damage. Previous studies have demonstrated the Neuroprotective effects of progesterone on regional brain ischemia and injury. In the present study, we investigate the Neuroprotective effects of progesterone on global brain ischemia as a result of cardiac arrest and resuscitation. Subjects:...

Mechanical cardiopulmonary resuscitation (m-CPR) devices are an alternative to manual CPR, but their efficacy has been subject to debate. We present a case of a patient with full-neurologic recovery after prolonged m-CPR. The patient presented with severe hypothermia (internal temperature 24°C) and poisoning (sedatives/hypnotics). Hepatic perfusion and metabolism are considered keys to restore ...

BACKGROUND Extracorporeal life support (ECLS) for cardiopulmonary resuscitation (CPR) may increase end organ perfusion and thus survival when conventional CPR fails. The aim was to investigate, if after ventricular fibrillation cardiac arrest in rodents ECLS improves outcome compared with conventional CPR. METHODS In 24 adult male Sprague-Dawley rats (460-510 g) resuscitation was started afte...