نتایج جستجو برای: meca protein

تعداد نتایج: 1236161  

2009
B. O. Olayinka

Methicillin-resistant Staphylococcus aureus has emerged as a serious threat to public health, causing both hospital and community-associated infections. The gold standard for MRSA detection is the amplification of the mecA gene that codes for the production of the altered penicillin-binding protein (PBP2a) responsible for classical methicillin resistance. This work determined the nature of meth...

2012
Antonella Montinaro Giovanni Forte Rosalinda Sorrentino Antonio Luciano Giuseppe Palma Claudio Arra Ian M. Adcock Aldo Pinto Silvana Morello

Cl-IB-MECA is a selective A3 adenosine receptor agonist, which plays a crucial role in limiting tumor progression. In mice, Cl-IB-MECA administration enhances the anti-tumor T cell-mediated response. However, little is known about the activity of Cl-IB-MECA on CD8+ T cells. The aim of this study was to investigate the effect of ex vivo Cl-IB-MECA treatment of CD8+ T cells, adoptively transferre...

Journal: :journal of basic research in medical sciences 0
mostafa nemati ilam morteza shamsi ilam

introduction: staphylococcus aureus (s. aureus) is a bacterium found on the skin and hair of people and animals. s. aureus could product some extracellular protein. materials and methods: one hundred and fifty s. aureus isolates that were collected from different resources were screened for the meca, tst-1, eta and etb genes by pcr. 50 isolates were selected from human staphylococcal isolates a...

Journal: :Antimicrobial agents and chemotherapy 2010
Sae Tsubakishita Kyoko Kuwahara-Arai Takashi Sasaki Keiichi Hiramatsu

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important multidrug-resistant pathogens around the world. MRSA is generated when methicillin-susceptible S. aureus (MSSA) exogenously acquires a methicillin resistance gene, mecA, carried by a mobile genetic element, staphylococcal cassette chromosome mec (SCCmec), which is speculated to be transmissible across staphylococcal...

Journal: :Journal of clinical microbiology 2001
R Zbinden M Ritzler E Ritzler B Berger-Bächi

In a recent article, Hussain et al. evaluated a commercial latex agglutination test (LA), the MRSA-Screen (Denka Seiken Co., Niigata, Japan), for rapid detection of penicillinbinding protein 2a (PBP2a) in mecA-positive and mecA-negative coagulase-negative staphylococci (CNS) (2). The sensitivity and specificity were 100 and 99.5% (2), respectively, although the MRSA-Screen was initially develop...

Journal: :Journal of clinical microbiology 2012
Katie A Sharff Stefan Monecke Sarah Slaughter Graeme Forrest Chris Pfeiffer Ralf Ehricht Margret Oethinger

Oxacillin-susceptible, mecA-positive Staphylococcus aureus isolates create a treatment challenge for the clinician. In this article, we describe two cases of bacteremia from isolates that carried the mecA gene but were susceptible to oxacillin (oxacillin-susceptible methicillin-resistant S. aureus [OS-MRSA]). DNA microarray analysis was used to characterize these isolates as a mecA-positive, cl...

Journal: :Hiroshima journal of medical sciences 1999
T Santo E Hiyama Y Takesue Y Matsuura T Yokoyama

The intrinsic resistance of methicillin-resistant Staphylococcus aureus (MRSA) is frequently explained by the production of an additional penicillin-binding protein (PBP), which is encoded by the mecA gene. The mec regulator genes, mecR1 and mecI, was identified in mecA-carrying Staphylococcus aureus N315. Between February and March, 1993, 179 clinical MRSA isolates were collected from institut...

Journal: :Antimicrobial agents and chemotherapy 2014
Feng-Jui Chen Chen-Her Wang Ching-Yi Chen Yu-Chieh Hsu Kaun-Ting Wang

The most prevalent community-associated methicillin-resistant Staphylococcus aureus (C-MRSA) strains in Taiwan, sequence type 59 (ST59) clones, carry staphylococcal cassette chromosome mec (SCCmec) type V and, to a lesser extent, type IV. These strains show wide variation in sensitivity to oxacillin, but the reasons for this variation are unknown. Here we compared the sequences of the mecA gene...

Journal: :Journal of bacteriology 2013
Xiao-Lin Tian Gaofeng Dong Tianlei Liu Zubelda A Gomez Astrid Wahl Pascal Hols Yung-Hua Li

Streptococcus mutans develops competence for genetic transformation through a complex network that receives inputs from at least two signaling peptides, competence-stimulating peptide (CSP) and sigX-inducing peptide (XIP). The key step of competence induction is the transcriptional activation of comX, which encodes an alternative sigma factor, SigX (σ(X)), controlling the expression of late com...

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