neonatal sepsis, a life-threatening condition, presents with non-specific clinical manifestations and needs immediate empirical antimicrobial therapy. choosing an appropriate antibiotic regimen covering the most probable pathogens is an important issue. in this study we compared the effectiveness of ceftizoxime and amikacin in the treatment of neonatal sepsis both in combination with ampicillin...

abstract objective: to assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. methods: this was prospective study conducted over a period of one year from december 2009 to november 2010 in neonatal intensive care unit of dduh hospital, a tertiary care hospital in delhi, north india. all babies who were admitted during this perio...

Introduction: Neonatal sepsis, and Neonatal septiemia are terms that have been used to describe the systemic response to infection in newborn infants. Sepsis can affect neonatal metabolism and the level of blood sugar. The aim of this study is to assess the prevalance of “Hypoglycemia” in neonates with primary diagnosis of sepsis in neonatal ward and NICU of khorrammabad pediatric hospital on...

Background: Early detection of neonatal sepsis and categorization of patients based on clinical severity is not yet effectively achieved. Some hematological parameters are used to formulate a hematological scoring system (HSS) and a modified hematological scoring system (MHSS) to diagnose neonatal sepsis. A promising biomarker: Presepsin, or Soluble Cluster of Differentiation 14 SubType (sCD14-...

Background: Neonatal sepsis is a life-threatening disease with an incidence of 1 to 10 per 1000 live births and a mortality rate of 15% to 50%. The clinical signs are non-specific and indistinguishable from those caused by a variety of neonatal noninfectious disorders. Objective: The aim of this study was to determine the importance of CD64 expression (FcgRI), a neutrophil surface marker, in ea...

Abstract Objective: To assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. Methods: This was prospective study conducted over a period of one year from December 2009 to November 2010 in neonatal intensive care unit of DDUH Hospital, a tertiary care hospital in Delhi, North India. All babies who were admitted during this perio...

Multi-antibiotic drug-resistant (MDR) gram-negative bacilli are becoming a major threat to the standard care of septic patients. Empiric antimicrobial drug regimens to cover likely bacterial pathogens have to be altered in keeping with the spread of MDR pathogens in the health care setting and in the community. Reliable antibiotics for broad spectrum coverage for sepsis such as extended spectru...

background: neonatal sepsis is a major cause of mortality and morbidity, especially in developing countries. the goal of the present study was to determine the bacterial etiology and antibiotic sensitivity patterns of neonatal sepsis.   methods: this cross sectional study was conducted on 208 neonates admitted with clinically suspected sepsis over a period of 30 months. sepsis was divided into ...

INTRODUCTION Recent evidence suggests a link between excess lipid peroxidation and specific organ failures in sepsis. No study has been performed in sepsis by multidrug-resistant (MDR) Gram-negative bacteria. METHODS Lethal sepsis was induced in rats by the intraperitoneal injection of one MDR isolate of Pseudomonas aeruginosa. Produced malondialdehyde (MDA) was measured in tissues 5 hours af...

Background: Neonatal sepsis is a major cause of mortality and morbidity, especially in developing countries. The goal of the present study was to determine the bacterial etiology and antibiotic sensitivity patterns of neonatal sepsis. Methods: This cross sectional study was conducted on 208 neonates admitted with clinically suspected sepsis over a period of 30 months. Sepsis was divided into ea...