This paper introduces a Minimum Description Length (MDL) principle to de ne tness functions in Genetic Programming (GP). In traditional (Koza-style) GP, the size of trees was usually controlled by user-de ned parameters, such as the maximum number of nodes and maximum tree depth. Large tree sizes meant that the time necessary to measure their tnesses often dominated total processing time. To ov...

MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-dependent manner. At a moderate concentration (~20 µM), MDL-12330A mainly induced apoptotic death wher...

In this paper we present a part of Casl-Mdl, a visual modelling notation based on Casl-Ltl (an extension for dynamic system of the algebraic specification language Casl). The visual constructs of Casl-Mdl have been borrowed from the UML, thus existing editors may be used. A Casl-Mdl model is a set of diagrams but it corresponds to a Casl-Ltl specification, thus Casl-Mdl is a suitable means to e...

The replacement of amino acids 1 and 3 of glycopeptide antibiotics (dalbaheptides) with new amino acids or other chemical entities suitable to interact with both glycopeptide-resistant (D-Ala-D-Lactate) and susceptible (D-Ala-D-Ala) targets is one of the chemical strategies currently followed to pursue activity against highly glycopeptide-resistant VanA enterococci while maintaining activity ag...

The IMIRSEL (International Music Information Retrieval Systems Evaluation Laboratory) project provides an unprecedented platform for evaluating Music Information Retrieval (MIR) and Music Digital Library (MDL) techniques, by bringing together large corpora and significant computational resources with the necessary rights management and technical infrastructure to support a variety of MIR/MDL re...

In this paper we extend modal dependence logic MDL by allowing dependence atoms of the form dep(φ1, . . . , φn) where φi, 1 ≤ i ≤ n, are modal formulas (in MDL, only propositional variables are allowed in dependence atoms). The reasoning behind this extension is that it introduces a temporal component into modal dependence logic. E.g., it allows us to express that truth of propositions in some ...

Phorbol esters which activate protein kinase C (PKC) have been shown to enhance experimental lung metastasis. Therefore, it was reasoned that inhibitors of PKC might also modulate metastasis. We have investigated this possibility using a PKC inhibitor, MDL 27,032 [4-propyl-5(4-pyridinyl)-2(3H)-oxazolone], as well as staurosporine and H-7. Treatment of B16F1 murine melanoma cells with MDL 27,032...

Materials and methods We used two human MDL tissue samples, three human MDL cell lines (UW473, UW472 and DAOY), three human cerebellum tissue samples and two human cerebellum primary culture. The cell lines were characterized morphologically by light microscopy and immunophenotypically by flow cytometry. MDL cell lines and tissue samples, as well as, control cerebellum primary culture and tissu...

MDL 62,879 (GE2270 A) is a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu. MDL 62,879 was very active against gram-positive clinical isolates, particularly staphylococci and enterococci, for which MICs for 90% of isolates were < or = 0.13 micrograms/ml. It was equally active against isolates resistant to beta-lactams, erythromycin, gentam...