نتایج جستجو برای: mcv

تعداد نتایج: 2435  

Journal: :Blood 2010
Yanis L Tolstov Reety Arora Susan C Scudiere Klaus Busam Preet M Chaudhary Yuan Chang Patrick S Moore

Koljonen et al described an association between chronic lymphocytic leukemia (CLL) and Merkel cell polyomavirus (MCV)– positive Merkel cell carcinoma (MCC) in a recent large populationbased survey from Finland.1 CLL has been reported as a tumor significantly associated with MCC, validating the general findings of this study.2,3 This association suggests the possibility that MCV may play a role ...

2013
Lindsay R. Dresang Anna Guastafierro Reety Arora Daniel Normolle Yuan Chang Patrick S. Moore

Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with high mortality. Merkel cell polyomavirus (MCV), discovered in 2008, is associated with ~80% of MCC. The MCV large tumor (LT) oncoprotein upregulates the cellular oncoprotein survivin through its conserved retinoblastoma protein-binding motif. We confirm here that YM155, a survivin suppressor, is cytotoxic to MCV-positiv...

2013
KATHRYN C. HOURDEQUIN JOEL A. LEFFERTS JEOFFRY B. BRENNICK MARC S. ERNSTOFF GREGORY J. TSONGALIS J. MARC PIPAS

The Merkel cell polyomavirus (MCV) is involved in the development of up to 100% of Merkel cell cancer (MCC) cases. Early studies have reported that the virus was infrequently detected in other small cell or neuroendocrine lung carcinomas, which share histological features with MCC. The present study investigated the presence of MCV in cases of extrapulmonary small cell carcinoma (ESCC), which a...

Journal: :Cancer research 2012
Christoph Willmes Christian Adam Miriam Alb Lena Völkert Roland Houben Jürgen C Becker David Schrama

Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer associated with the Merkel cell polyomavirus (MCV). As MCC cell lines show oncogene addiction to the MCV T antigens, pharmacologic interference of the large T antigen (LTA) may represent an effective therapeutic approach for this deadly cancer. In this study, we investigated the effects of IFNs on MCC cell lines, especially...

2010
Franziska Renger Holger Bang Eugen Feist Gert Fredenhagen Alexander Natusch Marina Backhaus Gerd-R Burmester Karl Egerer

INTRODUCTION Autoantibodies against mutated and citrullinated vimentin (MCV) represent a novel diagnostic marker for rheumatoid arthritis (RA). Recently, an increased sensitivity for anti-MCV compared to autoantibodies against cyclic citrullinated peptides (anti-CCP2) was shown in cohorts of patients with early RA and established disease.The aim of this study was to develop and evaluate a point...

2015
Hyun Ae Jung Hyun-Jun Kim Chi Hoon Maeng Se Hoon Park Jeeyun Lee Joon Oh Park Young Suk Park Ho Yeong Lim Won Ki Kang

PURPOSE Capecitabine is known to increase mean corpuscular volume (MCV). To define the incidence of capecitabine-induced macrocytosis and its association with chemotherapy outcomes, we investigated data of 89 patients with advanced gastric cancer (AGC) who were enrolled in a randomized chemotherapy trial involving capecitabine. MATERIALS AND METHODS Chemotherapy-naïve AGC patients were treate...

Journal: :Circulation journal : official journal of the Japanese Circulation Society 2013
Tomoya Ueda Rika Kawakami Manabu Horii Yu Sugawara Takaki Matsumoto Sadanori Okada Taku Nishida Tsunenari Soeda Satoshi Okayama Satoshi Somekawa Yukiji Takeda Makoto Watanabe Hiroyuki Kawata Shiro Uemura Yoshihiko Saito

BACKGROUND Accumulating evidence suggests that hematopoiesis, especially erythropoiesis, is disturbed in heart failure (HF) for many reasons. Low hemoglobin and red blood cell distribution width have emerged as prognostic indicators of HF independent of classic predictors. The prognostic implication of mean corpuscular volume (MCV) in HF, however, is unknown. In this context, we investigated th...

Journal: :Current opinion in virology 2012
Reety Arora Yuan Chang Patrick S Moore

Merkel cell polyomavirus (MCV), discovered in 2008, is clonally integrated in ~80% Merkel cell carcinoma (MCC). MCV is a common skin flora and initiates cancer in susceptible hosts only after it acquires a precise set of mutations that render it replication incompetent. Both MCV large and small T proteins promote cancer cell survival and proliferation. Large T targets pocket proteins regulating...

2011
Karthik K Tennankore Steven D Soroka Kenneth A West Bryce A Kiberd

BACKGROUND Macrocytosis occurs in chronic hemodialysis (CHD) patients; however, its significance is unknown. The purpose of this study was to establish the prevalence and distribution of macrocytosis, to identify its clinical associations and to determine if macrocytosis is associated with mortality in stable, chronic hemodialysis patients. METHODS We conducted a single-centre prospective coh...

Journal: :Carcinogenesis 2003
Akira Yokoyama Tetsuji Yokoyama Taro Muramatsu Tai Omori Sachio Matsushita Susumu Higuchi Katsuya Maruyama Hiromasa Ishii

Early esophageal squamous cell carcinoma detected by esophageal iodine staining can be easily treated by endoscopic mucosectomy, and identifying its predictors is important in better selecting candidates to screen for this high-mortality cancer. The common etiologies of elevated mean corpuscular volume (MCV) and esophageal cancer, including folate deficiency, smoking, drinking and high acetalde...

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