نتایج جستجو برای: mcu
تعداد نتایج: 769 فیلتر نتایج به سال:
Age-related sarcopenia is characterized by a progressive loss of muscle mass with decline in specific force, having dramatic consequences on mobility and quality of life in seniors. The etiology of sarcopenia is multifactorial and underlying mechanisms are currently not fully elucidated. Physical exercise is known to have beneficial effects on muscle trophism and force production. Alterations o...
Mitochondrial calcium uniporter (MCU) channel is responsible for Ruthenium Red-sensitive mitochondrial calcium uptake. Here, we demonstrate MCU oligomerization by immunoprecipitation and Förster resonance energy transfer (FRET) and characterize a novel protein (MCUb) with two predicted transmembrane domains, 50% sequence similarity and a different expression profile from MCU. Based on computati...
The wire is connected to an interrupt pin of an ATmega1284p MCU of an INGA sensor node. The input pins of this MCU are fused by two diodes per default. Thus, the potentially high voltage that is induced in the wire cannot harm the MCU. A pinchange interrupt is used to trigger the rising and the falling edge of the signal while a timer is fired to measure the period of positive half-waves of the...
The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.
Mitochondrial Ca(2+) homeostasis, the Ca(2+) influx-efflux balance, is responsible for the control of numerous cellular functions, including energy metabolism, generation of reactive oxygen species, spatiotemporal dynamics of Ca(2+) signaling, and cell growth and death. Recent discovery of the molecular identity of the mitochondrial Ca(2+) uniporter (MCU) provides new possibilities for applicat...
Triple-negative breast cancer (TNBC) represents the most aggressive breast tumor subtype. However, the molecular determinants responsible for the metastatic TNBC phenotype are only partially understood. We here show that expression of the mitochondrial calcium uniporter (MCU), the selective channel responsible for mitochondrial Ca(2+) uptake, correlates with tumor size and lymph node infiltrati...
This paper describes the development of a microinstrumentation system in silicon containing all the components of the data acquisition system, such as sensors, signal-conditioning circuits, analog-digital converter, interface circuits, sensor bus interface, and an embedded microcontroller (MCU). The microinstrumentation system is to be fabricated using the Multi-Chip-Module (MCM) technology bas...
The mitochondrial calcium uniporter (MCU) maintains intracellular Ca2+ homeostasis by transporting Ca2+ from the cell cytosol into the mitochondrial matrix and is important for shaping Ca2+ signals and the activation of programmed cell death. Inhibition of MCU by ruthenium red (RR) or Ru360 has previously been reported to protect against neuronal death. The aim of the present study was to analy...
Parasitic bipolar mechanisms can effectively prevent MCUs of redundant flip-flop, which improve the tolerance of soft errors. Device-level simulations reveals that no MCU occurs in redundant latches storing the opposite values by the parasitic bipolar effect, while MCU occurs by a particle hit with high energy in the redundant latches storing the same value.
• IF 1 regulates MCU-dependent mitochondrial Ca 2+ uptake. loss induces MCU upregulation through activation of the AMPK/CREB pathway. OMA1 depletion restores physiological levels and entry.
Trypanosoma cruzi is the agent of Chagas disease, and the finding that this parasite possesses a mitochondrial calcium uniporter (TcMCU) with characteristics similar to that of mammalian mitochondria was fundamental for the discovery of the molecular nature of MCU in eukaryotes. We report here that ablation of TcMCU, or its paralog TcMCUb, by clustered regularly interspaced short palindromic re...
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