In Xenopus, estrogen induces the stabilization of vitellogenin mRNA and the destabilization of albumin mRNA. These processes correlate with increased polysomal activity of a sequence-selective mRNA endonuclease, PMR-1, and a hnRNP K homology-domain RNA-binding protein, vigilin. Vigilin binds to a region of the vitellogenin mRNA 3'-untranslated region (3'-UTR) implicated in estrogen-mediated sta...

The power of resistance of reed stands against mechanical impact by waves and drifting matter is assessed using the mechanical properties of the stem wall (modulus of elasticity, breaking stress), the dimensions of the stem's cross section (diameter, momentum of inertia), and the culm density. The power of resistance of an individual stem (pmr) was found to be proportional to the bending stiffn...

The relationship between protein mutations and conformational change can potentially decipher the language relating sequence to structure. Elsewhere, we presented the Protein Mutant Resource (PMR), an online tool that systematically identified related mutants in the Protein DataBank (PDB), inferred mutant Gene Ontology classifications using data-mining, and allowed intuitive exploration of rela...

Objective: Polymyalgia rheumatica (PMR) is an inflammatory rheumatic disease that affects elderly people and is associated with synovitis. Recently, matrix metalloproteinase 3 (MMP 3) and vascular endothelial growth factor (VEGF) were reported to be involved in the pathogenesis of PMR-related synovitis. New evidence regarding the pathogenesis of PMR has been found; however, the diagnosis and ou...

Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. PMR-associated hepatotoxicity has been drawing increasingly more attention in recent years in parallel with its wide utilization. Anthraquinones (AQs) are recognized as the main hepatotoxic components in PMR. However, the exact underlying mechanism of AQs poisoning is still not fully understood. Herein, we...

OBJECTIVES Progressive muscle relaxation (PMR) is one of the self-management relaxation techniques that can be used in the general population and patients with specific issues. However, no study to date has revealed the brain activity associated with PMR. Therefore, we assessed the changes in brain activity induced by PMR using functional magnetic resonance imaging (fMRI). DESIGN AND SETTING ...

OBJECTIVE To explore primary care polymyalgia rheumatica (PMR) patient beliefs about the causes of their PMR. DESIGN Qualitative content analysis was conducted on patients' written responses to the question of what they thought had caused their PMR. All data were coded and emergent categories of causal beliefs identified. SETTING Community patients receiving primary care at general practiti...

OBJECTIVES The diagnostic diversity of polymyalgia rheumatica (PMR) can easily be obscured by the widespread use of corticosteroids (CSs) early in the disease course. This study observed the course of PMR without CSs and determined whether alternative medication could be useful. METHODS Seventy patients with new-onset PMR comprised phase 1. Eight were removed with specific diagnoses (four wit...

The rapid spreading of polymyxin E (colistin) resistance among bacterial strains through the horizontally transmissible mcr-1 and mcr-2 plasmids has become a serious concern. The emergence of these genes in Shiga toxin-producing Escherichia coli (STEC), a group of human pathogenic bacteria was even more worrisome, urging us to investigate the prevalence of mcr genes among STEC isolates. A total...

The cohort of 768 workers who were actively employed for a minimum of 6 months and died was retrospectively followed from 1 January 1953 to 31 December 2000. There were 328 women and 440 men observed. Proportionate mortality ratios (PMRs) were calculated using the Minsk-city population mortality proportions to generate expected numbers. The significant excess of pancreatic cancer (PMR=366%; 95%...