Objective: To compare the effect of a single induction dose of etomidate or ketamine on plasma cortisol levels in children with Tetralogy of Fallot (TOF) undergoing intra-cardiac repair on cardiopulmonary bypass (CPB). Design: A prospective randomized trial. Setting: Cardiac center of a tertiary care hospital. Participants: Thirty children with TOF undergoing intra-cardiac repair on CPB. Interv...

Plasma concentrations of metronidazole are proportional to the administered dose. Oral administration of 250 mg, 500 mg, or 2,000 mg produced peak plasma concentrations of 6 mcg/mL, 12 mcg/mL, and 40 mcg/mL, respectively. Studies reveal no significant bioavailability differences between males and females; however, because of weight differences, the resulting plasma levels in males are generally...

OBJECTIVES The aim of this study was to evaluate the accuracy of the Multifunction CardioGram (MCG) in detecting the presence of functionally significant coronary ischaemia. METHODS AND RESULTS This prospective study evaluated the accuracy of the MCG, a new ECG analysis device used to diagnose ischaemic coronary artery disease (CAD). A consecutive 112 participants suspected to have CAD who we...

School of Marilia, São Paulo, Brazil; Flow Citometry, and; Dermatology, Medical School of Marilia, Marilia, Brazil. Background: The prevalence of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) is high and its in vitro diagnostic is a challenge. The basophil activation test with determination by flow cytometry (FC), of the expression rate of CD63 molecules has been much studie...

In magnetocardiography (MCG) the magnetic field, produced by the electrical activity of the heart, is measured. This paper presents the preliminary results of the human fetal magnetocardiography (FMCG). The MCG of an adult heart was first recorded by BAULE and McFEE [1]. Recently, several research groups have utilized the superconducting quantum interference device (Squiü) in recording the MCG ...

Antibacterial activity and phytochemical tests of eight whole plant methanol extracts belonging to family Euphorbiaceae were evaluated. In agar well diffusion assay the diameter of inhibition zones ranged from 3-13 mm. Phyllanthus emblica showed maximum activity of 13 mm. The MIC and MBC observed were 30-140 mcg/ml and 40-160 mcg/ml, respectively. P. piscatorum and P. emblica showed the lowest ...

Plasma concentrations of metronidazole are proportional to the administered dose. Oral administration of 250 mg, 500 mg, or 2,000 mg produced peak plasma concentrations of 6 mcg/mL, 12 mcg/mL, and 40 mcg/mL, respectively. Studies reveal no significant bioavailability differences between males and females; however, because of weight differences, the resulting plasma levels in males are generally...

The autonomic nervous system regulates cardiac function by modulating heart rate and cardiac contractility. Changes in sympathetic and parasympathetic activity have effects on the amplitude and duration of the cardiac action potentials and conduction velocity. So far, no studies have been published on changes in MCG caused by rapid autonomic adaptation. For clinical applications of MCG it is im...

OBJECTIVE To evaluate the diagnostic outcomes of magnetocardiography (MCG) on the patients with coronary artery disease and compared the outcomes between MCG, ECG and Echocardiography. METHODS MCG measurements were performed on 101 patients with coronary artery disease and 116 healthy volunteers with a seven-channel magnetocardiographic system (MCG7, SQUID AG, Germany) installed in an unshiel...

PURPOSE To evaluate the safety and ocular hypotensive efficacy of 4 trabodenoson doses administered twice daily over 14 or 28 days in subjects with ocular hypertension or primary open-angle glaucoma (POAG). METHODS In this multicenter, randomized, double-masked, placebo-controlled, dose-escalation Phase 2 study, patients received unilateral topical twice-daily trabodenoson (50, 100, or 200 mc...