Bevirimat [BVM, PA-457, 3-O-(3',3'-dimethylsuccinyl)-betulinic acid], a new anti-human immunodeficiency virus drug candidate, is metabolized to two monoglucuronides [mono-BVMG (I) and mono-BVMG (II)] and one diglucuronide (di-BVMG) both in vivo and in vitro. UDP-glucuronosyltransferase (UGT) reaction screening, enzyme kinetics, and species differences for the glucuronidation of BVM in vitro wer...

In this paper we summarize recent results on finding tight semidefinite programming relaxations for the Max-Cut problem and hence tight upper bounds on its optimal value. Our results hold for every instance of Max-Cut and in particular we make no assumptions on the edge weights. We present two strengthenings of the well-known semidefinite programming relaxation of Max-Cut studied by Goemans and...

In the past two years we have lived through the most serious financial and economic crisis in the lives of practically everyone on this earth today. Not surprisingly, and not inappropriately, it has led to profound attempts to rethink where we stand on a number of issues. The area of development economics so beloved by Max Fry, and to which he devoted much of his professional effort, was certai...

In the present work, the behavior of He in the MAX phase Ti3AlC2 material is investigated using first-principle methods. It is found that, according to the predicted formation energies, a single He atom favors residing near the Al plane in Ti3AlC2. The results also show that Al vacancies are better able to trap He atoms than either Ti or C vacancies. The formation energies for the secondary vac...

Extreme environmental phenomena such as major precipitation events manifestly exhibit spatial dependence. Max-stable processes are a class of asymptotically-justified models that are capable of representing spatial dependence among extreme values. While these models satisfy modeling requirements, they are limited in their utility because their corresponding joint likelihoods are unknown for mor...

The oncogenic bHLH-LZ transcription factor Myc forms binary complexes with its binding partner Max. These and other bHLH-LZ-based protein-protein interactions (PPI) in the Myc-Max network are essential for the physiological and oncogenic activities of Myc. We have generated a genetically determined and highly specific protein-fragment complementation assay based on Renilla luciferase to analyze...

We investigated the effects of estrogens on the regulation of dopamine receptors in the MtT/W15 transplantable rat pituitary tumor. Diethylstilbestrol (DES) and 17beta-estradiol treatment in female rats significantly decreased the number of dopamine binding sites (B max) from 85 +/- 3.9 fmol/mg protein in untreated rats to 9.2 +/- 1.2 and 8.2 +/- 2.8 fmol/mg protein in DES and 17beta-estradiol-...

The Max protein belongs to the basic region-helix-loop-helix-leucine zipper family of transcriptional regulators. Max heterodimerizes with Myc family proteins to form sequence-specific DNA-binding complexes. In order to elucidate the potential role of Myc and Max during amphibian embryogenesis, we have isolated and analyzed the expression of two Xenopus Max complementary DNAs: XMax1 and XMax2. ...

this study was conducted to evaluate the effect of probiotic bactocell, a-max and inflammatory breast prebiotic mixture of these two compounds on growth, feed and larval survival of rainbow trout (oncorhynchus mykiss) conducted for 84 days. testing a randomized complete block design consisting of zero (control), 1.0, and 2.0 grams of probiotic bactocell, 5/1 and 5/2 grams of prebiotic a-max and...