The aim of present work was to optimize the effect of Ethyl Cellulose (EC) and Polyvinyl Pyrrolidone (PVP) concentration in extended release solid dispersion of Glibenclamide using combination of hydrophilic and hydrophobic polymers such as Polyvinyl Pyrrolidone and Ethyl cellulose. The advantage of solid dispersion technique provides a unique approach to particle size reduction and increased r...

meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. the aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (peg) 6000. the effect of solubilization by...

A simple and effective multiresidue method based on precipitation at low temperature followed by matrix solid-phase dispersion-sonication was developed and validated to determine dimethoate, malathion, carbaryl, simazine, terbuthylazine, atrazine and diuron in palm oil using liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS). Liquid-liquid extraction (LLE) followed by low temper...

stable homogeneous dispersions of carbon nanotubes (cnts) were prepared using ethanol as dispersing agent. then, using sol-gel method, dispersion in the hydroxyapatite matrix and its effects on the microstructure were investigated. the phase composition, chemical structure and morphological and size analyses were performed using xrd, ft-ir, sem, tem/saed/edx and raman spectroscopy. the influenc...

the first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using peg 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. the second objective was to apply the modified solvent method for preparation of sustained release ...