The progressive bronchial dilatation in bronchiectasis is likely to be the result of continued airway matrix destruction, although little is known about the role of neutrophil matrix metalloproteinases (MMPs) in this process. Immunohistochemistry has been used to investigate the expression and cellular localisation of MMP-8 and MMP-9 in bronchiectatic airways in vivo. Endobronchial biopsies wer...

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have pivotal functions in extracellular matrix turnover and are involved in chronic kidney diseases. However, the exact functions of MMPs in chronic renal failure (CRF) have yet to be demonstrated. The aim of the present study was to examine the effects of MMP-9 on CRF. An adenine-induced model of CRF was gener...

Matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs), whose expression can be controlled by cytokines, play a role in extracellular matrix remodeling in physiological and pathological processes. Using a blister chamber wound model on UV-B-exposed human forearm skin, we examined whether stress or mood-associated neuroendocrine alteration is sufficient to modul...

Knowledge on the role of matrix metalloproteinases (MMPs) in adenoid cystic carcinoma (ACC) is limited. MMPs are capable degrading almost all extracellular and pericellular components to promote invasion metastasis. This study aimed evaluate immunohistochemical expression MMP-7, -8, -9, -15, -25 ACC relate results with clinicopathological factors survival. The included 68 patients minor salivar...

PURPOSE Extracellular matrix metalloproteinase inducer (EMMPRIN) has been shown to stimulate fibroblasts to production of matrix metalloproteinases (MMPs). MMPs comprise a family of proteolytic enzymes implicated in the degradation of extracellular matrix which has been proposed to be one of the essential steps in tumor invasion and metastases. In the present study we investigated the expressio...

OBJECTIVE To determine whether matrix metalloproteinases (MMPs) are present long-term in human corneas after successful laser-assisted in situ keratomileusis (LASIK). METHODS Eighteen postmortem corneas from 10 patients with postoperative intervals of 2 to 8 years after LASIK surgery and 4 normal control corneas from 2 patients were collected from US eye banks and processed for histologic ana...

background: matrix metalloproteinases comprise a family of enzyme degrade components of extra cellular matrix. there are single nucleotide polymorphisms in the promoter regions of several genes with ability to influence cancer susceptibility. the aim of this study was to analyze association between mmp 3 promoter polymorphisms and colorectal cancer occurrence and progression. materials and meth...

Highlights . Elevated levels of matrix metalloproteinases 2 and 9 are associated with the initiation severity CHF developed after breast cancer therapy anthracyclines, which may contribute to cardiac remodeling progression systolic dysfunction. Concentrations metalloproteinases-2 -9 in blood serum serve as predictors unfavorable course anthracycline-induced heart failure. Aim To assess role (MM...

BACKGROUND AND OBJECTIVE Orthodontic tooth movement requires remodeling of the periodontal tissues. The matrix metalloproteinases (MMPs) degrade the extracellular matrix components of the periodontal ligament, while the tissue inhibitors of metalloproteinases (TIMPs) control their activity. Synthetic MMP inhibitors have been developed to inhibit MMP activity. In this study, periodontal ligament...

objective: obesity increases production of the extracellular matrix (ecm) role in pathological cardiovascular damage. regular exercise and the use of medicinal plants, particularly celery, in damage to be effective. the aim of this study is to investigate the changes in matrix metalloproteinases 2,9 (mmp 2,9) and tissue inhibitor of matrix metalloproteinase 1 (timp-1) with synchronized exercise...