OBJECTIVES To examine whether there is an association between neighbourhood deprivation and diagnosed childhood obesity, after accounting for family- and individual-level socio-demographic characteristics. METHODS An open cohort of all children aged 0-14 years was followed between January 1, 2000 and December 31, 2010. Childhood residential locations were geocoded and classified according to ...

It has been reported that periodic maternal separation in rats leads to a variety of endure behavioral, neurochemical and microstructural sequelae associated with the pathophysiology of anxiety disorders. Since it has been proposed that these changes might be permanent, we examined whether environmental complexity aid to recover the structural dendritic impairment induced by neonatal maternal d...

The fetal "programming of adult diseases" has been previously reviewed. The descriptions were comprehensive, dealing with the effects of nutritional deprivation on the development of adult metabolic and cardiovascular diseases. During the past decade, research into this "programming" also expanded to the development of osteoporosis. The present review deals with the imbalance of bone mineral me...

This paper presents a case of an emotionally deprived child with some evidence of child neglect resulting from separation of parents (maternal deprivation). It also further confirms the long recognized fact that the most successful treatment of growth failure and weight loss due to psychosocial deprivation is restoration of a normal social environment. In particular, it highlights the need for ...

Some children exposed to socioeconomic (SES) deprivation are resilient and function better than expected, given the level of deprivation they have experienced. The present study tested genetic and environmental contributions to young children's resilience and vulnerability to SES deprivation. Children's resilience was assessed by the difference between their actual score and the score predicted...

In this study we tested whether periodic maternal deprivation (MD) (4.5 h daily during the first 3 weeks of life) caused chronic changes in anxiety and medullo-adrenal responses to chronic stress in either male or female adult (2.5 months of age) rats, or both. Repeated maternal deprivation had a sex-specific effect on epinephrine (E) and norepinephrine (NE) levels: an increase in both measures...

Twenty-four hours of maternal deprivation result in activation of the infant rat's adrenocortical axis. In the present study we examined the long-term effects of maternal deprivation on the corticosterone (Cort) response to stress. Pups were maternally deprived (Dep) on postnatal day( PND) 11 and tested immediately ( PND 12) or returned to their mothers and tested at later ages. Testing consist...

Introduction The placenta is responsible for nutrient delivery to the fetus by the combined action of transport activities in the apical (maternal-facing) and basal (fetal-facing) membranes. We have described the developmental regulation of cationic amino acid transport in the rat placenta [I]. During the period of greatest fetal nutritional need, the final third of gestation, the placenta up-r...

BACKGROUND There is now ample evidence that schizophrenia is due to an interaction between genetic and (early) environmental factors which disturbs normal development of the central nervous system and ultimately leads to the development of clinical symptoms. Recently, we showed that a single 24-hour period of maternal deprivation of rat pups at postnatal day 9 leads to a disturbance in prepulse...