Objective: To study the antianaphylactic, antihistaminic and mast cell stabilization activity of HK-07 in experimental animals. Materials and Methods: HK-07 is a polyherbal formulation containing extracts of various plant constituents. The compound HK-07 was evaluated using Wistar rats and Duncan Hartley guinea pigs. The antianaphylactic activity was investigated in rats using the active anaphy...

Tryptase was previously shown to undergo rapid inactivation under physiological conditions unless stabilized by the presence of heparin. The current study shows that increasing the concentration of free tryptase enhances the preservation of enzymic activity, consistent with dissociation of the tetramer, rather than autodegradation, as the mechanism of inactivation. Heparin glycosaminoglycan fra...

background : functional dyspepsia is considered one of the most common digestive diseases with tremendous cost and time expenditures for patients and health systems. an increase in the numbers of inflammatory cells such as mast cells and eosinophils are reported in the gastrointestinal mucosa of these patients. this study aims to determine the effects of histaminic receptor blockage on patients...

background: the aim of this study was to quantify the number of mast cells in focal reactive hyperplastic lesions of the oral cavity and to compare these two number of mast cells in normal gingival tissues and to correlate their presence with the state of connective tissue changes in reactive lesions and probably suggest a role for mast cells in these lesions. materials and methods: patient rec...

Degranulation of isolated, rat peritoneal mast cells in the presence of low density lipoprotein (LDL) induces cholesteryl ester accumulation in cocultured macrophages with ensuing foam cell formation. This event occurs when the macrophages phagocytose LDL particles that have been bound to the heparin proteoglycans of exocytosed granules. In an attempt to inhibit such foam cell formation pharmac...

background and aims. mast cells are one of the characteristic factors in angiogenesis, growth, and metastatic spread of tumors. the distribution and significance of mast cells in many tumors have been demonstrated. however, few studies have evaluated mast cell infiltration in salivary gland tumors. in this study, mast cell counts were evaluated in benign and malignant salivary gland tumors. mat...

background & objectives: odontogenic cysts are among the most frequent destructive lesions of jaws which their pathogenesis and growth mechanism are not cleared. with respect to different roles of mast cells, they may play a role in the pathogenesis and growth of odontogenic cysts. the aim of present study was to evaluate mast cells in the most common odontogenic cyst. methods: thirty  para...

OBJECTIVES The significance of the mast cell in the pathogenesis of rheumatic diseases has become more evident. Although mast cell hyperplasia is a feature of rheumatoid arthritis, the nature of mast cell chemoattractants involved in the recruitment of mast cells in joint diseases has not been studied in any detail. In this study the presence of mast cell chemotactic activity in synovial fluids...