نتایج جستجو برای: mark2
تعداد نتایج: 1487 فیلتر نتایج به سال:
LKB1, a tumor suppressor gene mutated in the Peutz-Jeghers syndrome, encodes a serine/threonine protein kinase. Recent biochemical studies have shown that LKB1 activates 14 AMP-activated protein kinase-related kinases including MARKs (microtubule-associated protein/microtubule affinity-regulating kinases) that regulate microtubule dynamics. Here we show in vitro that LKB1 phosphorylates and act...
MARK, a kinase family related to PAR-1 involved in establishing cell polarity, phosphorylates microtubuleassociated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, and their disassembly. The sites are prominent in tau from Alzheimer's disease brains. We studied the activation of MARK and identi®ed the upstream kinase, MARKK, a member of the Ste20 kinase family. It ...
Obesity is a major factor central to the development of insulin resistance and type 2 diabetes. The identification and characterization of genes involved in regulation of adiposity, insulin sensitivity, and glucose uptake are key to the design and development of new drug therapies for this disease. In this study, we show that the polarity kinase Par-1b/MARK2 is required for regulating glucose m...
The Par-1 protein kinases are conserved from yeast to man and belong to a subfamily of kinases that includes the energy sensor and metabolic regulator, AMPK. Par-1 is regulated by LKB1 and atypical PKC and has been shown in multiple organisms and cell types to be critical for regulation of cellular polarity. Recent studies using knockout mice have revealed several surprising physiological funct...
Electrical Impedance Tomography (EIT) has potential for imaging of the head to image cerebral edema and stroke, and to assist the EEG inverse problem. One key challenge is the low distinguishability of head EIT. In this paper, we develop a strategy to improve distinguishability by optimizing electrode configurations and stimulation and measurement patterns. In a hemispherical simulation phantom...
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