BACKGROUND Peptic ulcer etiology has been changing because of H. pylori decline. OBJECTIVES To estimate peptic ulcer prevalence in 10 years-interval and compare the association with H. pylori and use of non-steroidal anti-inflammatory drugs. Methods Records assessment in two periods: A (1997-2000) and B (2007-2010), searching for peptic ulcer, H. pylori infection and non-steroidal anti-inflam...

BACKGROUND Diagnoses of peptic ulcer are registered in the Danish National Patient Registry (DNPR) for administrative as well as research purposes, but it is unknown whether the coding validity depends on the location of the ulcer. OBJECTIVE To validate the International Classification of Diseases, 10th revision diagnosis codes of peptic ulcer in the DNPR by estimating positive predictive val...

The pronounced geographical and temporal variations in gastric and duodenal ulcer suggest that important environmental factors must play a part in their aetiology. To determine the nature of possible factors, the Registrar General's decennial supplement and the vital statistics special reports of the United States Department of Health, Education, and Welfare on occupational mortality were analy...

Pressure ulcer trials often use development of category≥2 pressure ulcers as an endpoint [1]. Research nurses regularly assess patient’s skin to capture pressure ulcer development, however missed assessments may lead to missed pressure ulcers and capturing data from routine care may be an alternative. Pressure ulcer monitoring systems have been introduced in the English NHS including the Safety...

“The most important undertaking in science is the establishment of experimental methods”—Ivan P. Pavlov (1849— 1936). Pavlov’s statement is readily applicable to ulcer research, i.e., establishing an experimental ulcer model that resembles human ulcers is of utmost importance. Nonetheless, although easily stated, developing an experimental method can prove difficult, especially when such a meth...

BACKGROUND Prostaglandin E which is present abundantly in the gastric mucosa is a powerful inhibitor of gastric acid secretion and a stimulus to gastric mucus production. In addition, prostaglandin E2 inhibits ulcer formation in animals, and the synthetic analogues of prostaglandin E have successfully been used in the treatment of patients with gastric and duodenal ulcer disease. To evaluate th...

Although various markers have been used in attempts to elucidate the mode of inheritance of duodenal ulcer, they have not significantly contributed to a clear understanding of the problem. In the present study total serum pepsinogen was used as a genetic marker and its concentrations were estimated in 100 ulcer patients and their family members up to three generations. Eighty three per cent of ...

Previous studies have suggested that patients operated upon for duodenal ulcer who have a previous history of perforation or haemorrhage are particularly liable to haemorrhage after operation from a proved or probable stomal ulcer (Langman, 1965). The cause of this association is unknown but there is evidence that patients of blood group 0 are particularly prone to duodenal ulcer haemorrhage (L...

Background & Aim: Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties.  Experimental: The effects of ethanol stem extract of H. letestui (200 – 600 mg/kg) and fractions (Aqueous and Dichloromethane, 400 mg/kg) on experimentally in...