Marine actinomycetes were isolated from the sediments collected from Coromandel Coast region, India. The strain designated as BI244 was found to be an efficient pigment (dark brown-black) producer and has been selected for further studies. The organism was identified as Streptomyces sp. based on morphological, biochemical and physiological characterization. Phylogenetic tree constructed for 16s...

In our screening of marine Streptomycetes for bioactive compounds, in addition to the known metabolites rabelomycin (1), fridamycin D (2b), N-benzylacetamide and N-(2'-phenylethyl)acetamide, two new anthracycline antibiotics designated as himalomycin A (2c) and B (2d) were isolated from the culture broth of the marine Streptomyces sp. isolate B6921. The structure of the new antibiotics was dete...

Heterologous expression of secondary metabolic pathways is a promising approach for the discovery and characterization of bioactive natural products. Herein we report the first heterologous expression of a natural product from the model marine actinomycete genus Salinispora. Using the recently developed method of yeast-mediated transformation-associated recombination for natural product gene cl...

Aromatic polyketides from marine actinomycetes have received increasing attention due to their unusual structures and potent bioactivities. Compared to their terrestrial counterparts, marine aromatic polyketides have been less discovered and their structural and biological diversities are far from being fully investigated. In this study, we employed a PCR-based genome mining method to discover ...

Marine-derived actinomycetes have demonstrated an ability to produce novel compounds with medically relevant biological activity. Studying the diversity and biogeographical patterns of marine actinomycetes offers an opportunity to identify genera that are under environmental pressures, which may drive adaptations that yield specific biosynthetic capabilities. The present study describes researc...

The response of two marine actinomycetes such as Streptomyces sp. MADO2 and Nocardiopsis sp. MADO3 to osmotic stress in minimal medium M63 and in glycerol-asparagine medium (ISP5) was studied. The two strains were moderately halophilic and the behavior of the strain Streptomyces sp. MADO2 and Nocardiopsis sp. MADO3 towards the salt stress was varied depends on the media composition and the sali...

Marine Streptomyces sp.VITBRK3 isolated from the sediment sample collectedat the Marakkanamcoast located in the Southeast coastal region of Bay of Bengal, India. The ethyl acetate extract was prepared from the culture supernatant of Streptomyces sp.VITBRK3.The anti-MRSA compound was purified by silica gel column chromatography and HPLC. The purified compound was identified by using H and C NMR ...

The main aim of the study was to evaluate the antimicrobial, antioxidant and cytotoxic potential of crude extract of Marine Streptomyces species isolated from soil of Chennai coast, Tamilnadu. Primary and Secondary screening for antimicrobial activity was determined by Cross streak method and Agar well diffusion method respectively. Gram positive bacteria were found most sensitive to the actino...

Metabolomics and genomics are two complementary platforms for analyzing an organism as they provide information on the phenotype and genotype, respectively. These two techniques were applied in the dereplication and identification of bioactive compounds from a Streptomyces sp. (SM8) isolated from the sponge Haliclona simulans from Irish waters. Streptomyces strain SM8 extracts showed antibacter...