Sascha H.C. Duttke,1,8 Scott A. Lacadie,4,8 Mahmoud M. Ibrahim,4,5 Christopher K. Glass,2,3 David L. Corcoran,7 Christopher Benner,6 Sven Heinz,2,6 James T. Kadonaga,1,* and Uwe Ohler4,5,* 1Section of Molecular Biology 2Department of Cellular and Molecular Medicine 3Department of Medicine University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA 4Berlin Institute for Medic...

2017 marks the second year of the International Society for Computational Biology (ISCB) Innovator Award, which recognizes an ISCB scientist who is within two decades of having completed his or her graduate degree and has consistently made outstanding contributions to the field. The 2017 winner is Dr. Aviv Regev, Professor of Biology at the Massachusetts Institute of Technology (MIT), a Core Me...

Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based ...

1 Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, 2 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, 3 Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America, 4 Institu...

A40 Persistent circulation of highly divergent HIV-1M lineages in the Congo Basin Region M. Tongo, J.R. Dorfman, Tulio de Oliveira, D.P. Martin, Africa Centre for Population Health, University of KwaZulu-Natal, South Africa, Division of Computational Biology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, Institute of Medical Research and Stud...

programme. Unlike THOR, which exclusively dealt with the observation and modelling of the ocean and climate, NACLIM, which is also chaired by Detlef Quadfasel at Hamburg, aims to link this research to marine biology. “Biology lags far behind the physical sciences when it comes to mechanistic understanding and prediction,” says Payne. “Even if we could characterise the ocean perfectly in infinit...

1 Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA 99352, USA 2Department of Electrical and Computer Engineering, The University of Texas at San Antonio, San Antonio, TX 78249, USA 3Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA 4Center for Quantitative Sciences, Vanderbilt University Me...

1 Marine and Environmental Sciences Centre (MARE) and Institute of Marine Research (IMAR), University of the Azores, Horta, Portugal, 2 Department of Oceanography and Fisheries, University of the Azores, Horta, Portugal, 3 Pacific Islands Fisheries Science Center, National Marine Fisheries Service, National Oceanographic and Atmospheric Administration, Honolulu, HI, USA, 4 Hawaii Institute of M...