BACKGROUND Patients with bipolar disorder often show decreased adherence with mood stabilizers and frequently interventions on prodromal depressive and manic symptoms are delayed. Recently, the MONARCA I randomized controlled trial investigated the effect of electronic self-monitoring using smartphones on depressive and manic symptoms. The findings suggested that patients using the MONARCA syst...

BACKGROUND Bipolar disorder is a chronic mood disorder with episodic progress and high relapse rate. Growing evidence suggests that individuals with bipolar disorder display cognitive impairment which persists even throughout periods of symptom's remission. METHOD 137 bipolar patients met the inclusion criteria (depressive episode: DSM-IV-TR criteria for major depressive episode, HAMD score ≥...

Inconsistencies in the relation between COMT variation and schizophrenia may be clarified by careful delineation of a target phenotype. The present study reports a significant association between a COMT haplotype and the severity of manic symptoms in 162 patients with schizophrenia or schizoaffective disorder (SZ). These data suggest that the effect of COMT variation may be associated with como...

Correspondence to: Dalibor Karlović, Department of Psychiatry, University Hospital Center Sestre milosrdnice, Vinogradska cesta 29, 10000 Zagreb email: [email protected] Introduction Bipolar disorder (BD) is a complex psychiatric entity, which represents a diagnostic as well as a therapeutic challenge in clinical practice. The very definition and classification of BD is determined by a...

In general, bipolar disorder with its classical presentation of regularly recurring manic and depressive episodes can be well diagnosed in adults and adolescents. However, bipolar disorder in children is a controversial issue, difficult to diagnose and to distinguish from other illnesses that frequently occur in childhood. In the US, where the diagnosis of'bipolar disorder' is made relatively o...

OBJECTIVE The aim of this study was to translate the Structured Clinical Interview for Mood Spectrum into Brazilian Portuguese, measuring its reliability, validity, and defining scores for bipolar disorders. METHOD Questionnaire was translated (into Brazilian Portuguese) and back-translated into English. Sample consisted of 47 subjects with bipolar disorder, 47 with major depressive disorder,...

BACKGROUND Reported rates of bipolar syndromes are highly variable between studies because of age differences, differences in diagnostic criteria, or restriction of sampling to clinical contacts. METHOD In 1395 adolescents aged 14-17 years, DSM-IV (hypo)manic episodes (manic and hypomanic episodes combined), use of mental health care, and five ordinal subcategories representing the underlying...

objective: to report the case of a 46-year old male with major depressive disorder, who represented manic symptoms, when olanzapine was added to his treatment. method: a 46-year old female, with a diagnosis of treatment resistant depression was referred to the authors. he had past history of depression for more than 20 years. the symptoms were present nearly every day since 1981, without any di...

Even though neurofibromatosis ( NF) is not a rare neurological disorder, but there is few studies regarding  the relationship between  NF and psychological disorders. A 14 year old girl with NF type 1 associated  with multiple cerebral lesions was admitted in psychiatric ward due to restlessness , hypertalktiveness aggressive behavior, and flight of idea. Psychiatric diagnosis, based on DSM IV ...