The dose-related response of the mammary growth was studied in immature ICR-JCL female mice given 0.03 micrograms of estradiol per animal subcutaneously, and 0.005-1.0mg of either of the following phenothiazines (chlorpromazine, levometh iomeprazine, promethazine, perphenazine, thioridazine and propericiazine) per 10g of body weight was given orally once a day for 9 days starting on the 5th day...

University of Konstanz and for coaching me through the project. Thanks to the Haematox group for the scientific but also personal support: you are not only colleagues but really good friends! Thanks to Dr. Michele Reni for the constant presence, for the optimism and for making endurable the therapy. Finally, this work is dedicated to the most important people in my life: mamma, papa' and Tommaso.

Not long ago Professor Nussbaum treated a case of cancer of the mamma, with so strong a tendency to hemorrhage that each dressing of the ulcer threatened the woman's life. As the patient was nearly moribund from the frequent loss of blood, he surrounded the tumour with a strong subcutaneous ligature, which he drew together with all his strength and then tied. The result was not only an arrest o...