The results are reported of an ab initio study of the addition of LiAlH(4) to acetonitrile and malononitrile at the MP2(full)/6-311+G* level considering the effects of electron correlation at higher levels up to QCISD(T)/6-311++G(2df,2pd) and including ether solvation. All imide (RCH(2)CH═N(-)) and enamide (RCH(-)CH═NH ↔ RCH═CHN(-)H) adducts feature strong interactions between the organic anion...

Spinal ganglionic cells of Rana pipiens were studied with light and electron microscopes in normal animals and in animals which had received graded dosages of malononitrile intraperitoneally. After treatment no increase in the intensity of staining was noted in the Nissl substance when spinal ganglion cells were examined with the light microscope. The electron micrographs demonstrated the follo...

Butanamide derivative (1) coupls smoothly with arenediazonium salts to afford the hydrazone (3). The latter product reacts with dimethylformamide – dimethylacetal (DMF-DMA) and or malononitrile to afford the substituted 1,4dihydropyridazines (5,6). Several new pyran (8), thiophene (9), pyrazole (14) and isothiocyanate derivatives (17,18) have been synthesized by the reactions of butanamide with...

Highly substituted cyclopentenes can be accessed rapidly from isocyanides, aldehydes and malononitrile or ethyl cyanoacetate (AB2C2) using DABCO as a catalyst under solvent-free conditions at 40 °C within 30 min.

The Knoevenagel condensation between aromatic aldehydes and malononitrile, ethyl cyanoacetate or malonic acid with hydroxyapatite supported caesium carbonate in water is described. HAP-Cs₂CO₃ was found to be a highly active, stable and recyclable catalyst under the reaction conditions.

A simple, direct, sensitive, and selective stopped-flow method for the fluorimetric determination of uric acid in serum and urine samples is described. The variation of fluorescence intensity during the reaction between uric acid and 1,1,3-tricyano-2-amino-1-propene (triap) in the presence of hydrogen peroxide is monitored. For these kinetic measurements peroxide is monitored. For these kinetic...