Polyunsaturated fatty acids have been reported to enhance the cytotoxic activity of several anticancer drugs. In the present study, we observed that doxorubicin chemosensitization of breast cancer cell lines by docosahexaenoic acid (DHA, a long-chain omega-3 polyunsaturated fatty acid) was cell-line selective, affecting MDA-MB-231 and MCF-7 dox (a doxorubicin-resistant cell line) but not the pa...

PURPOSE To compare the antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the levels of lipid peroxidation product malondialdehyde (MDA) in blood samples of thyroid cancer patients compared to healthy controls. METHODS 43 control subjects (mean age 44+/-13 years) and 43 patients (43+/-13 years) presented with multinodular goiter whose fine needle ...

BACKGROUND Oxidative stress has been implicated in the development of endothelial damage in hemodialysis (HD). We have assessed the effects of N-acetylcysteine (NAC), a compound with antioxidant effects, on malondialdehyde (MDA), a marker of oxidative stress on lipid peroxidation. METHODS A clinical trial was conducted in which 24 chronic HD patients were divided into 2 groups according to ge...

Relationship among malondialdehyde (MDA), 2-thiobarbituric acid (TBA)-reactive substances (TBA-RS), and tocopherols in the oxidation of rapeseed oil was investigated. MDA was determined by a new HPLC method with chemical derivatization. When the oil was heated at 170 degrees C, TBA-RS and MDA increased. The contents of TBA-RS were approximately 1.6 times higher than those of MDA. Correlation be...

BACKGROUND Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases. Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA). SUBJECTS AND METHODS We measured MDA levels in EBC in a large number of patients (N = 194) with respiratory diseases: asthma (N = 64), bron...

Introduction: Malondialdehyde (MDA) is a useful determinant to show high level of lipid peroxidation which lead to impaired cell function. Previous studies have mentioned there is a relationship between high oxidative stress and low anti-oxidant activity in patients with oral lichen planus. The aim of this study was to evaluate serum level of Malondialdehyde as an indicator of oxidative stress ...

<p align="center"><strong><em> </em></strong></p><p><strong><em>Background:</em></strong><em> Hypertension is a disease that often occurs during pregnancy. Many factors influence the occurrence of hypertension, one which oxidative stress. Oxidative stress has an important role in pathogenesis hypertension pregnancy and may ...

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin associated with oxidative stress. The present study aimed to investigate the presence of oxidative stress in patients with newly diagnosed SLE. SLE patients (n = 36) and control subjects (n = 28) were enrolled in this study. Blood samples were used for malondialdehyde (MDA), sulfhydryl groups (SH) and uric acid determ...

Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) is increasing due to obesity sedentary lifestyles. Increased oxidative stress leads damage biomolecules decreased antioxidant capacity.Aim: study was designed determine the malondialdehyde (MDA) ferric reducing ability plasma (FRAP) in T2DM patients at IIMS&R Hospital, Lucknow.Method: analyzed as MDA. total capacity...