نتایج جستجو برای: malkin
تعداد نتایج: 106 فیلتر نتایج به سال:
In 1892, the general problem of stability by the first approximation was considered by Lyapunov. He proved that if the system of the first approximation is regular and all its Lyapunov exponents (or characteristic exponents) are negative, then the solution of the original system is asymptotically Lyapunov stable. In 1930, it was stated by O. Perron that the requirement of regularity of the firs...
During the 13 years which have passed since the p53 protein was first identified, studies of the p53 gene have gained in scientific importance, leading to discoveries with major clinical implications. Although originally classified as an oncogene, more recent results from a number of studies have established that the p53 gene exhibits properties conssistent with a tumour suppressor gene. Mutati...
Research partially supported by NSF grants DMS-9803181 and DMS-0103895, AFOSR grant F49620-96-1-0100, a University of Michigan Rackham Fellowship, and an NSF group infrastructure grant at the University of Michigan Research partially supported by NSF grants DMS-9803181 and DMS-0103895, AFOSR grant F49620-96-1-0100, and an NSF group infrastructure grant at the University of Michigan Research par...
Tor has grown beyond its original purpose as an anonymity tool and has become a widely-used cen sorship circumvention tool. This is the first study to ex amine Tor’s usability in this role. We evaluate, design, and test the Tor configuration interface by placing users in simulated censorship environments, instructing them to use Tor to circumvent censorship, and measuring their interactions w...
Juliette Larthe cofounded Prettybird in London with Kerstin Emhoff and Paul Hunter. As an executive producer she brought a multidisciplinary working manifesto culture to the start-up. works as across not just screen advertising but feature films, multimedia brand content, immersive, experiential art works, music short- long-form live installations fashion shows. Juliette’s work has earned her n...
Abstract Activation of DNA-sensing pathways can induce an anti-tumour immune response, but the mechanisms by which tumour-derived cell-free DNA (cfDNA) activates pro-inflammatory signaling is not well-understood. In particular, topological features cfDNA that contribute to sensor activation in phagocytes are unknown. As such, we investigated how topology influences macrophages and dendritic cel...
Institute for Global Health Innovation (L Conteh PhD, Prof A Darzi FRCS, P Howitt MA, K Kerr PhD, Prof S Matlin DSc, R Merrifi eld PhD, Prof G-Z Yang PhD), Centre for Environmental Policy (E Wilson MSc), Centre for Health Policy (D King MRCS, M Kulendran MRCS, Prof P C Smith BA), Department of Bioengineering (Prof A M J Bull PhD, Prof R A Malkin PhD, Prof M M Stevens PhD), Department of Civil a...
“Prevention”: the Right Term? To the Editor: Rothwell needs to be complimented for highlighting the problems surrounding the terms “prevention” and “reduction in mortality.”1 Trialists, as Tan points out elsewhere,2 often concentrate mainly on the changes in the number of events (y axis) and ignore the changes on the time scale (x axis) in the analysis of survival curves. Malkin and Channer3 ha...
In 2009 we reported the fatal case of a toddler who had received codeine after adenotonsillectomy for obstructive sleep apnea syndrome. The child was an ultra-rapid metabolizer of cytochrome P4502D6 (CYP2D6). We now report 3 additional fatal or life-threatening cases from North America. In the 2 fatal cases, functional gene duplications encoding for CYP2D6 caused a significantly greater product...
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