Malignant hyperthermia is a subclinical myopathy in which general anesthesia triggers an uncontrollable contraction of skeletal muscle that leads to life-threatening hypercatabolic state and increase body temperature. The disease primarily autosomal dominant; mutations receptors (especially ryanodine receptor type 1) predispose volatile anesthetic agents or succinylcholine causing accumulation ...

The core myopathies are a subset of myopathies that present in infancy with hypotonia and muscle weakness. They were formerly considered a rare type of congenital myopathy but are now recognized as being more prevalent. Due to their genetic linkage to mutations in the ryanodine receptor gene (RYR1), core myopathies (in particular, central core disease) carry a high risk of malignant hyperthermi...