background: early detection of proneness to hypertension may help an individual to lead a healthy life by altering the life style. subjects having the predisposing factors of hypertension tend to show higher and prolonged responsiveness to blood pressure following stress. methods: normotensive, non-smoking healthy sedentary male students and staff of nepal medical college (n=50, age group 18-35...

the aim of this study was to assess cultural intelligence of volunteers for sport events. the method applied in this research was descriptive – analytical. the statistical population consisted of all sport volunteers at the 10th cultural-sport olympiad of iranian male and female university students. due to the low number of statistical population, the sample equaled the population (n=120). cult...

BACKGROUND/AIMS To report gastric emptying scintigraphy, normal values should be established for a specific protocol. The aim of this study was to provide normal gastric emptying values and determine factors affecting gastric emptying using Asian rice-based meal in healthy volunteers. METHODS One hundred and ninety-two healthy volunteers were included at 7 tertiary care centers across Thailan...

Sorbinil pharmacokinetics were studied, following a single oral dose, in eight male and eight female healthy, elderly volunteers. Elimination half-life tended to be longer in males than in females. There was no sex difference in AUC or renal clearance. The long elimination half-life of sorbinil in the elderly suggests that accumulation is likely to occur with chronic dosing.

The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label, randomized, balanced, multiple-dose, three-period crossover study. Fourteen subjects received t...

The current study evaluated the relationship between self-report and behavioral measures of impulsivity in 98 young adult male subjects. Principal components analysis of the self-report measures revealed four primary factors: the first demonstrated significant loadings with Eysenck’s Impulsivity and Nonplanning scales and all subscales of the Barratt Impulsivity Scale, the second with Eysenck’s...

BACKGROUND Visceral hyperalgesia is a hallmark of functional gastrointestinal disorders. Antidepressants improve symptoms in these patients, although their mode of action is unclear. Antidepressant, anticholinergic, and analgesic mechanisms have been proposed. AIMS To investigate whether imipramine, which has a visceral analgesic effect, increases pain thresholds to experimental visceral pain...

BACKGROUND Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III. PURPOSE The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers. METHODS We used 500 plasma concentration data poin...

The objective of this study was to investigate the bioequivalence of two formulations of 5 mg donepezil HCL tablets: Tonizep as the test and Aricept as the reference. The two products were administered as a single oral dose according to a randomized two-phase crossover with a 3-week washout period in 20 healthy Thai Male volunteers. After drug administration, serial blood samples were collected...

The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms). After intravenous administration, the pharmacokinetic profile could be described with a two-compartment model. The distribution half-life was 0.049 +/- 0.10...