The use of quantum dots (QDots) as bright and photostable probes for long-term fluorescence imaging is gaining more interest. Thus far, (pre)clinical use of QDots remains limited, which is primarily caused by the potential toxicity of QDots. Most QDots consist of Cd2+ ions, which are known to cause high levels of toxicity. Therefore, the cytotoxic effects of CdSe quantum dots on embryonic devel...

Guideline Title Detection of Toxicity to Reproduction for Medicinal Products Including Toxicity to Male Fertility *) Legislative basis Directive 75/318/EEC as amended Date of first adoption First adopted October 1983 This version incorporates version adopted September 1993 and addendum on male fertility adopted 1995. Date of entry into force June 1996 Status Last revised 1995 (male fertility) P...

Cadmium (Cd) is one of the most toxic environmental heavy metals to organisms. The prominent toxic effects of Cd on reproductive organs are very well known. Gonad histopathology is a valuable tool for the assessment of endocrine disruption compounds EDCs effects on fish. The aim of this study was to evaluate the reproductive toxicity of cadmium chloride (CdCl2) on histopathology of Zebrafish (D...

Results of a U.S.S.R.--U.S. cooperative laboratory effort to improve and validate experimental techniques used to assess subtle reproductive effects in male laboratory animals are reported. The present studies attempted to evaluate the reproductive toxicity of cadmium as cadmium chloride and boron as borax (Na2B4O7) and to investigate the mechanism of toxicity in the rat following acute and sub...