Mutations in SLURP1 cause mal de Meleda, a rare palmoplantar keratoderma (PPK). SLURP1 is a secreted protein that is expressed highly in keratinocytes but has also been identified elsewhere (e.g., spinal cord neurons). Here, we examined Slurp1-deficient mice (Slurp1(-/-)) created by replacing exon 2 with β-gal and neo cassettes. Slurp1(-/-) mice developed severe PPK characterized by increased k...

While the first traces of interest in skin diseases date back to the 14(th) century recipes from Glagolitic manuscripts, the scientific beginnings of dermatovenereology might be associated with the beginning of the 19(th) century, when in the Rijeka region a 'new disease', called after the village of Škrljevo, was studied by Giovanni Battista Cambieri. This, however, has not been the only disea...

MAIN OUTCOME MEASURE Clinical features of mal de debarquement syndrome. RESULTS Nearly all respondents were middle-aged women (26 of 27; mean age, 49.3 years). The duration of symptoms ranged from 6 months to 10 years (mean, 3.5 years; SD, 2.5 years). The symptoms were constant in 23 (85%) patients. Neither meclizine hydrochloride nor transdermal scopolamine was helpful. Benzodiazepines were ...

Nagashima-type palmoplantar keratosis (NPPK) is an autosomal recessive form of palmoplantar keratoderma (PPK), which is caused by mutations in the SERPINB7 gene. NPPK has only been reported in Japanese and Chinese populations. The present study was conducted on 12 unrelated Chinese patients who were clinically predicted to suffer from NPPK. Mutation screening was performed by direct sequencing ...

BACKGROUND SLURP1 is the causal gene for Mal de Meleda (MDM), an autosomal recessive skin disorder characterized by diffuse palmoplantar keratoderma and transgressive keratosis. Moreover, although SLURP1 likely serves as an important proliferation/differentiation factor in keratinocytes, the possible relation between SLURP1 and other skin diseases, such as psoriasis and atopic dermatitis, has n...

Mal de Debarquement Syndrome (MDS) is a rare, understudied, underdiagnosed, and self-limiting condition. Etiology and incidence are unknown. It is characterized by abnormal sensation of motion/balance reported after travel by air, land, and sea; being reexposed to motion/activity relieves it. Symptoms may last from minutes to years. Workup though required reveals no findings; it is a diagnosis ...

Sea travel mandates changes in the control of the body. The process by which we adapt bodily control to life at sea is known as getting one's sea legs. We conducted the first experimental study of bodily control as maritime novices adapted to motion of a ship at sea. We evaluated postural activity (stance width, stance angle, and the kinematics of body sway) before and during a sea voyage. In a...

the closing ceremonies to mark the conclusion of our humanitarian efforts. Despite the oppressive, unrelenting heat, stifling body odor, the poverty surrounding us, and our longing to be reunited with family, the soldiers and airmen of Combined Joint Task Force Bravo were extremely proud of their accomplishments after months of being in El Salvador. This task force had been deployed to El Salva...

Mal de debarquement, or "land sickness," is a transient sensation of tumbling, swinging, unsteadiness, and disequilibrium reported by passengers and crew after returning to land from long sea voyages. Although mal de debarquement is mentioned in classic texts on seasickness,' 2 there are no specific studies concerning the nature and extent of this phenomenon. A computer search of the literature...