PURPOSE To determine magnetization transfer ratios for normal head and neck structures so that evaluation of disease will be possible. METHODS Two-dimensional magnetization transfer imaging was performed in 12 healthy volunteers and 20 patients. We used a repetition time of 500, echo time of 12, 20 degrees flip angle, and a magnetization transfer pulse offset from the resonance frequency of w...

Chemical exchange saturation transfer (CEST) imaging is a relatively new magnetic resonance imaging contrast approach in which exogenous or endogenous compounds containing either exchangeable protons or exchangeable molecules are selectively saturated and after transfer of this saturation, detected indirectly through the water signal with enhanced sensitivity. The focus of this review is on bas...

The eŠect of rigor (formation of actomyosin complexes) on magnetization transfer was observed with a 1.5T clinical magnetic resonance (MR) imaging system. The magnetization transfer ratio of chemically skinned (calcium-sensitive) muscle ˆber preparations increased much more in a rigor state than in a relaxed state, while that of calcium-insensitive ˆber preparations and solutions showed no diŠe...

PURPOSE To study the potential combined application of gadolinium and magnetization transfer in the MR imaging of intracranial tumors. METHODS Twenty-two patients were imaged at low field strength (0.1 T). Corresponding gradient-echo partial saturation images without and with magnetization transfer pulse were produced. Images with intermediate repetition times were obtained in 18 cases; five ...

BACKGROUND Neuroimaging studies suggest that schizophrenia is associated with gray and possibly white matter changes. It is unclear whether these changes are present at illness onset or which brain structures are selectively affected. New imaging methods such as magnetization transfer imaging may be more sensitive than conventional volumetric imaging to the subtle structural brain changes in sc...

One of several techniques that achieve contrast by preparing the magnetization in some way and then sampling the prepared magnetization via a conventional imaging sequence, magnetization transfer offers advantages that have proven valuable in the study of white matter disorders. In the most common implementation, the magnetization transfer preparation is integrated into a gradient echo pulse se...

PURPOSE To estimate the age of cerebral infarcts using magnetization transfer. METHODS Twelve patients with radiographically and clinically documented cortical and subcortical cerebral infarctions underwent MR imaging on a 0.1T magnet. Magnetization transfer contrast images were generated by application of off-resonance pulses to every other repetition time on intermediate-weighted images. Th...

In this review article, conventional brain MRI and advanced MRI techniques in Parkinson`s disease (PD) are discussed, with emphasis on clinical relevance. Conventional brain MRI sequences generally demonstrate limited abnormalities specific for PD and in clinical practice brain MRI is mainly used to exclude other pathology. Possibly, brain MRI at higher magnetic field strengths could provide ne...