نتایج جستجو برای: macular degeneration
تعداد نتایج: 73965 فیلتر نتایج به سال:
Age-related macular degeneration is the leading cause of irreversible blindness in the United States and often coexists with chronic kidney disease. Both conditions share common genetic and environmental risk factors. A total of 1183 participants aged 54+ were examined in the population-based, prospective cohort Blue Mountains Eye Study (Australia) to determine if chronic kidney disease increas...
background degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. the principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. to briefly review the lines of research and potential candidates for cell based therapies among r...
OBJECTIVE To investigate the role of oxidant/antioxidant status and protein oxidation in the development of age-related macular degeneration. METHOD The activities of serum superoxide dismutase and glutathione peroxidase and the levels of serum malondialdehyde, advanced oxidation protein products, glutathione and vitamin C were measured in 25 patients with age-related macular degeneration and...
PURPOSE To investigate the relation between plasma concentrations of lutein and zeaxanthin and age-related macular degeneration in a group of elderly men and women. METHODS The Wisconsin Age-Related Maculopathy Grading System was used to grade features of early and late macular degeneration in 380 men and women, aged 66 to 75 years, from Sheffield, United Kingdom. Fasting blood samples were t...
PURPOSE To elucidate whether the gene polymorphisms of glutathione S-transferase (GST) M1, T1, and P1 are associated with the development of exudative age-related macular degeneration. METHODS The authors genotyped 35 white patients with exudative age-related macular degeneration and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defin...
purpose: to determine the prevalence and determinants of age-related macular degeneration (amd) in a 40-64 year old iranian populationmethods: in a cross-sectional study, 6,311 people were randomly selected from shahroud. for all participants, visual acuity, refraction, slit-lamp examination and fundus photography were conducted under pupil dilation. results: results of this study are based on ...
background: cells have complex network of antioxidant enzymes that protect cells from induced damages by reactive oxygen species (ros). catalase and superoxide dismutase are known for their role as primary protection against oxidative stress. oxidative damage is an important risk factor in age-related macular degeneration disease (amd). for the first time in this study the impact of genetic pol...
Gene therapy in age-related macular degeneration - IJCEO- Print ISSN No: 2395-1443 Online No:- 2395-1451 Article DOI 10.18231/j.ijceo.2023.001, Indian Journal of Clinical and Experimental Ophthalmology-Indian J Clin Exp Ophthalmol
Emerging treatments for dry age-related macular degeneration (AMD) and geographic atrophy focus on two strategies that target components involved in physiopathological pathways: prevention of photoreceptors and retinal pigment epithelium loss (neuroprotection induction, oxidative damage prevention, and visual cycle modification) and suppression of inflammation. Neuroprotective drugs, such as ci...
1. Doyle SL, campbell M, Ozaki E, et al. NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat. Med. 2012; 18: 791– 798. 2. tarallo V, Hirano Y, Gelfand BD, et al. DIcER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. cell 2012; 149: 847–859. 3. Kauppinen A, Niskanen H, Suuronen t,...
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