In this study we examined enhancement effects of Artemisinin plus Glucantime and shark cartilage extract, on promastigotes and amastigotes of L.infantum in in vitro condition.The toxicity of artemisinin, glucantime and shark cartilage extract on the L. infantum promastigotes and amastigote-infected macrophages was evaluated using MTT assay. The role of these drugs in inducing apoptosis in proma...

objective(s):some evidence showed that calcitriol has an important role in regulating growth and differentiation of mesenchymal stem cells (mscs). however, the interaction between mesenchymal stem cells and macrophage is not clear yet.  the current study was done to investigate the in vitro effects of calcitriol on the interactions between bone marrow-derived mscs and rat macrophages. materials...

in this study the nature of chromosomal proteins, his tones and nonhistone in resident alveolar macrophages was investigated in comparison to peritoneal neutrophils and calf thymus proteins. cells were obtained by lavaging the lung and after purity determination they were subjected to fractional extraction procedures. proteins were then analysed on sds polyacrylamide gels and densitometric scan...

background: macrophages have important role in defense against herpes simplex virus type-1 (hsv-1). the present study was performed to determine the viability and nitric oxide (no) production by hsv-1 infected mouse peritoneal macrophages (him).   method: the viability of macrophages was evaluated using mtt reduction assay and the production of nitrite using griess method.   results: the abilit...

nitric oxide (no) derived from activated macrophages has been shown to be crucial for the host's leishmanicidal activities. excess no, however, can in¬duce apoptosis in some cell types, including macrophages. in the present inves¬tigation, we studied the role of no in inducing apoptosis of balb/c mice mac¬rophages infected with leishmania major in vitro. the peritoneal macrophages were harveste...

Objective(s) Previous studies have demonstrated that the nitric oxide (NO) dependent death of murine peritoneal macrophages activated in vitro with IFN-g and LPS is mediated through apoptosis. In the present study, we investigated the synergistic effect of LPS, IFN-g and iron on NO production and apoptosis. Materials and Methods After determination of iron cytotoxicity, the peritoneal macrop...

conclusions the data indicate that esat6-cfp10 could support the survival of m. tuberculosis in the host through altering the host immune response. it also indicates that the host may gain some level of protection from a second exposure to m. tuberculosis, as evidenced by increased proliferation of nr8383-ec. background mycobacterium tuberculosis is the major pathogen of tuberculosis, which aff...