نتایج جستجو برای: macrophage migration inhibitory factor mif

تعداد نتایج: 1102207  

Journal: :Journal of Enzyme Inhibition and Medicinal Chemistry 2021

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine playing crucial role in immunity. MIF exerts unique tautomerase enzymatic activity that has relevance concerning its multiple functions and small molecule inhibitors have been proven to block effects. Here we demonstrate some of the E-2-arylmethylene-1-tetralones their heteroanalogues efficiently bind MIF’s active site ...

2009
Madelijn Geldhoff Barry B Mook-Kanamori Diederik van de Beek

Bacterial meningitis is a complex disorder in which injury is caused, in part, by the causative organism and, in part, by the host's own inflammatory response. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a neuro-endocrine mediator that might play a role in pneumococcal meningitis. Here, we discuss the role of MIF in infection, the brain, and corticosteroids a...

Journal: :Mediators of Inflammation 2004
Tadamichi Shimizu Hironori Niizeki Osamu Takeuchi Yuichiro Yamasaki Nobuko Inamoto Yukihiro Kusunoki Kunihiko Kobayashi Riichiro Abe Hiroshi Shimizu Takeji Nishikawa Kazuhiro Hashiguchi Jun Nishihira

We investigated the serum macrophage migration inhibitory factor (MIF) levels of palmoplantar pustulosis patients, before and after the tonsillar provocation test. Higher serum MIF levels of palmoplantar pustulosis patients were decreased after the tonsillar provocation test (n=29). To confirm these phenomena, two patients with acute tonsillitis had their changes in body temperature, C-reactive...

Journal: :The Journal of Urology 2021

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology (MP08)1 Sep 2021MP08-05 BLADDER MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) RECEPTORS MEDIATE PAIN Shaojing Ye, Fei Ma, Dlovan Mahmood, Katherine Meyer-Siegler, Raymond Menard, David Hunt, Lin Leng, Richard Bucala, and Pedro Vera YeShaojing Ye More articles by this author , MaFei Ma MahmoodDlovan Mahmood Meyer...

Journal: :Journal of immunology 2005
Nicole D Powell Tracey L Papenfuss Melanie A McClain Ingrid E Gienapp Todd M Shawler Abhay R Satoskar Caroline C Whitacre

Macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of inflammatory and autoimmune diseases. The role of MIF in the progression of experimental autoimmune encephalomyelitis (EAE) was explored using MIF-/- mice. Wild-type mice showed a progressive disease course, whereas MIF-/- mice exhibited acute signs but no further progression of clinical disease. MIF-/- mice...

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