It is well known that dopamine (DA) modulates, via D1 receptors, the activity of the dorsolateral prefrontal cortex (DLPFC) for working memory in monkey with an inverted-U shape profile. The activity of the DLPFC is moderate and D1 receptors in the DLPFC are activated rather modestly. We studied the circuit dynamics of the DLPFC for wider variation of the cortical extracellular DA concentration...
