نتایج جستجو برای: lysosomal disorders
تعداد نتایج: 684439 فیلتر نتایج به سال:
Lysosomal storage diseases comprise a group of about 40 disorders, which in most cases are due to the deficiency of a lysosomal enzyme. Since lysosomal enzymes are involved in the degradation of various compounds, the diseases can be further subdivided according to which pathway is affected. Thus, enzyme deficiencies in the degradation pathway of glycosaminoglycans cause mucopolysaccharidosis, ...
Autophagy-lysosomal pathway (ALP), a lysosome-mediated self-renewal process, is crucial for cell survival and death. Acrylamide (AA) neurotoxic compound produced during food thermal processing, the mechanism underlying AA-induced neurotoxicity remains elusive. In this study, we explored whether dysregulated ALP was involved in mechanism. We first evaluated toxic effects of AA on activation apop...
Lysosomal storage diseases (LSDs) are a class of metabolic disorders caused by mutations in proteins critical for lysosomal function. Such proteins include lysosomal enzymes, lysosomal integral membrane proteins, and proteins involved in the post-translational modification and trafficking of lysosomal proteins. There are many recognized forms of LSDs and, although individually rare, their combi...
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