The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on th...

RNA synthesis in isolated brain nuclei was analyzed 2.5 hr after the intravenous administration of d-lysergic acid diethylamide (LSD) to young rabbits. The drug stimulated transcription by 54% in brain stem nuclei and by 13% in cerebral hemisphere nuclei expressed over saline controls. Both nucleoplasmic and nucleolar RNA synthesis were increased. The main activity in the isolated nuclei assay ...

-Rats were trained on a multiple schedule of poskive reinforcement. A stimulus light source flickering at 100 eye!e/see provided the discriminative stimulus (Sa). Under the Sa cvndidon, reir, forcemer_t was contingent upon an FRI0 _chedule. Tke same light source flickering at 30 cycle/see constituted the S_ condition. Brom-lysergic acid diethyb amide (BOL), at doses of 1 and 3/_mol/kg had no ef...

LSD induces profound psychedelic effects, including changes in the meaning of percepts. The subjective effects of LSD are fully blocked by a 5-HT2A receptor antagonist. LSD may alter meaningfulness by increasing activity in cortical regions responsible for processing personal attribution.