Data from many laboratory and clinical investigations indicate that CD34+ cells comprise approximately 1% of human bone marrow (BM) mononuclear cells, including the progenitor cells of all the lymphohematopoietic lineages and lymphohematopoietic stem cells (stem cells). Because stem cells are an important but rare cell type in the CD34+ cell population, investigators have subdivided the CD34+ c...

Integrin-associated protein (CD47) is a broadly expressed protein that costimulates T cells, facilitates leukocyte migration, and inhibits macrophage scavenger function. To determine the role of CD47 in regulating alloresponses, CD47(+/+) or CD47(-/-) T cells were infused into irradiated or nonconditioned major histocompatibility complex disparate recipients. Graft-versus-host disease lethality...

OBJECTIVE To investigate whether workplace exposures to recognized lymphohematopoietic carcinogens were possibly related to cancers in six semiconductor-manufacturing workers. METHODS A job-exposure matrix was developed for chemical and physical process agents and anticipated by-products. Potential cumulative occupational exposures of the six cases were reconstructed. The role of workplace ex...

BACKGROUND The sequencing of the human genome has opened doors for global gene expression profiling, and the immense amount of data will lay an important ground for future studies of normal and diseased tissues. The Human Protein Atlas project aims to systematically map the human gene and protein expression landscape in a multitude of normal healthy tissues as well as cancers, enabling the char...

The purpose of this study was to review the existing studies on lymphohematopoietic (LHP) cancer in Korea, estimate the prevalence of workers exposed to carcinogens, and determine the population attributable fraction (PAF) of leukemia. Two case series and 4 case reports were reviewed. Using official statistics, the prevalence of benzene exposure and ionizing radiation exposure was estimated. Ba...

VIDENCE THAT INFUSION of syngeneic spleen or E marrow cells could protect mice and guinea pigs from lethal doses of irradiation' led Thomas et a1 to perform studies on total body irradiation (TBI) and marrow transplantation in dogs and eventually in human^.^-^ TBI was chosen because irradiation could be delivered expeditiously, did not generate metabolites that might interfere with the function...

conclusions with regards to the high incidence of gasterointestinal parasitic diseases and also because of asymptomatic cases of giardiasis, we recommend evaluation of pediatric patients with malignant lymphohematopoitic disease by at least two different diagnostic methods and three rounds of stool examination in order to prevent possible life threatening outcomes. coproparasitoscopic study for...

Multiple steps are involved in hematopoietic differentiation and maturation from multipotent progenitor cells to terminally differentiated cells of each lineage. The availability of recombinant growth factors and of various clonogenic precursor cell assays has provided useful information about hematopoietic precursors, notably of the myeloid lineage [13]. However, the direct evaluation of primi...