Multiple sclerosis (MS) is a complex neurological disease and its prevalence is about 2 million in the world. Neuroinflammation plays a key role in MS. Vitamins are essential nutrients that have effective role on immune system including activation of lymphocyte and differentiation of T-helper cell. Vitamin D is a micronutrient that is effective on immune function. Deficiently of Vitamin D is a ...

ML-133 is a novel small molecule with potent antiproliferative activity, as shown in cancer cell lines and in a human colon tumor xenograft model. ML-133 reduces the concentration of intracellular labile zinc in HT-29 colon cancer cells, leading to induction of the Krüppel-like factor 4 transcription factor. Krüppel-like factor 4 displaces the positive regulator SP1 from the cyclin D1 promoter,...

We have determined the influence of reference particle deformability and suspending buffer tonicity on the measurement of lymphocyte volume by an electronic particle volume analyzer. When the volume analyzer was standardized with latex spherules having a shape factor (f.) of 1 .5. red cell volume was 96 cu m and lymphocyte volume was 289 cu m. The red cell volume corresponded closely to the tru...

The immunosuppressive macrolide rapamycin and its derivative everolimus (SDZ RAD, RAD) inhibit the mammalian target of rapamycin (mTOR) signaling pathway. In this study, we provide evidence that RAD has profound antiproliferative activity in vitro and in NOD/SCID mice in vivo against Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) cells. Moreover, we identified 2 molecular mecha...

Introduction. Difficulties in advanced pancreatic ductal adenocarcinoma (PDAC) treatment require a constant search for novel prognostic factors. The aim of this study is to determine the role various morphological parameters pre­dicting prognosis PDAC during systemic therapy with FOLFIRINOX regimen. Material and methods. data 52 patients, treated chemotherapy due metastatic were analyzed retros...

Recent studies have demonstrated that advanced neoplastic disease is often associated with a general impairment of im mune function (15, 17, 29). High levels of serum immunoreg ulatory factors which nonspecifically inhibit in vitro and in viva lymphocyte function (13, 17, 21 , 25, 28, 39, 40, 45) are thought to account for the depressed immune status of anergic cancer patients (13, 33). Further...

the cypress family, cupressaceae, has a global dispersion. currently, endophytic microorganisms from plants are being investigated for their diversity and bioactivities. here, we aimed at exploration and characterization of cultivable endophytic fungi from foliar tissues of cupressaceae, i.e. cupressus arizonica, c. sempervirens var. cereiformis, c. sempervirens var. fastigiata, juniperus excel...

Thieno[3,2-d]pyrimidine as an effective pharmacophore has been extensively studied. However, its 2,6-substituted derivatives are rarely reported. In the present study, eighteen 2,6-substituted thieno[3,2-d]pyrimidine derivatives containing electrophilic warheads were designed based on the first known Fibroblast growth factor receptor-4 (FGFR4) inhibitor Blu9931. Unexpectedly, all of the derivat...