background evaluation of operational risk is a consequential goal in perioperative management of patients in cardiac surgery. preoperative total lymphocyte count (ptlc) is a prognostic criterion of adverse major cardiovascular outcomes. objectives the purpose of this study was to investigate the prognostic value of ptlc as an independent predictor of postoperative morbidity and mortality in car...

background: the appendix is considered as part of the gut-associated lymphoid tissue; however, lymphocyte subsets in this tissue are not fully defined. objective: to investigate and compare the function and phenotype of lymphocyte subsets in peripheral blood and appendix of patients with normal and inflamed appendix tissues. methods: peripheral blood samples and appendiceal mononuclear cells we...

many cellular damages either in normal or cancerous tissues are the outcome of molecular events affected by ionizing radiation. t‑cells are the most important among immune system agents and are used for biological radiation dose measurement in recommended standard methods. the herbs with immune modulating properties may be useful to reduce the risk of the damages and subsequently the diseases. ...

conclusions the leptin can also be used for the treatment of severe and intractable l. monocytogenes and e. coli infection. results our data demonstrates that leptin is able to induce cd11b expression on neutrophils but this induction is significantly less than l. monocytogenes. indeed, cells treated with leptin had lower amounts of apoptosis compared with untreated cells. the highest amount of...

Objective: To investigate the short – and long-term dynamics in inflammation markers [systemic immune-inflammation index (SII),
 neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), lymphocyte/ monocyte (LMR)] before after
 biological disease-modifying antirheumatic drugs (bDMARD) or targeted synthetic DMARD (tsDMARD) treatment.
 Patients Methods: wo hundred twenty-six p...

immunophenotyping of lymphocytes is very essential for evaluation of immune system. due  to  the  effect  of  environmental  factors  and  ethnical diversity on  immune  system, establishment of an internal normal range of lymphocyte subsets is a necessity for each population.  the  aim  of  this  study  was  to  determine  the  normal  range  of  t  and  b lymphocytes, and nk cells in normal i...

objective: hypericum perforatum (st. john's wort) has long been used in traditional medicine to treat a variety of internal and external ailments. the present study was done to evaluate the immumodulatory potentials of the hydroalcoholic extract of h. perforatum. materials and methods: twenty male balb/c-mice were randomly allocated in two equal groups and immunized with sheep red blood ce...

background: the purpose of this paper is to establish an easy and reliable biodosimeter protocol to evaluate the biological effects of proton beams. materials and methods: human peripheral blood lymphocytes were irradiated using proton beams (let: 34.6 kev μm−1), and the chromosome aberrations induced were analyzed using cytokinesis-blocked (cb) micronucleus (mn) assay. to determine the efficie...

objective(s): systemic candidiasis is an infection of candida albicans (c. albicans) causing disseminated disease and sepsis, invariably when host defenses are compromised. we investigated the histopathological changes as well as the lymphoproliferative responses and cytokine production of splenic cells after stimulation with concanavalin a (con a) and pokeweed mitogen (pwm) in mice with dissem...