AIMS To develop a specific test for lupus anticoagulant activity with reduced sensitivity to coagulation factor deficiency that would be suitable for analysis of plasmas from patients receiving oral anticoagulants. METHODS A coagulation test based on the Taipan snake venom time (TSVT) with a platelet neutralisation procedure (PNP) was developed and compared with dilute Russell's viper venom t...

Antiphospholipid syndrome (APS) is an acquired prothrombotic state characterized by recurrent thromboses, pregnancy loss, thrombocytopenia, and the presence of antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant and/or anti2-glycoprotein antibody. The original clinical and laboratory criteria for APS, called the Sapporo criteria, were first published in 1999. These were...

the central immunological disturbance in systemic lupus erythematosus (sle) is autoantibody production. some of these antibodies affecting components of the cell nucleus are the major characteristics of sle. the present study was aimed to assess importance of anticardiolipin (acl) antibody and its association with clinical state in sle patients. a cross sectional study was performed on 100 pati...

BACKGROUND Lupus anticoagulants prolong clotting times in phospholipid-dependent coagulation tests. Lupus Ratio assays are integrated tests for lupus anticoagulants that may be based on APTT, RVVT or dPT clotting times. If a patient is being treated with unfractionated heparin, however, the heparin prolong clotting times and the diagnosis of lupus anticoagulant is invalidated. Commercial assays...

INTRODUCTION Multiple factors, including proteinuria, antiphospholipid syndrome, thrombocytopenia and hypertension, are predictive of pregnancy loss in systemic lupus erythematosus (SLE). In the PROMISSE study of predictors of pregnancy loss, only a battery of lupus anticoagulant tests was predictive of a composite of adverse pregnancy outcomes. We examined the predictive value of one baseline ...

A 23-year-old woman with systemic lupus erythematosus and secondary antiphospholipid antibody syndrome presented with 1-month history of persistent low back pain radiating to the left flank. She had been maintained on lowdose corticosteroid and anticoagulant for more than 3 years. Plain radiography of the lumbar spine revealed no abnormality. However, L-spine magnetic resonance images (MRIs) sh...

Laboratory diagnosis of APS relies on the demonstration of positive antiphospholipid antibodies (aPL), including anticardiolipin antibody (aCL) and/or anti2 glycoprotein I antibody (anti2GPI) by an in-house or commercially available enzyme-linked immunosorbent assay (ELISA) or lupus anticoagulant (LA) by a coagulation-based test. The relationship between aPL and thrombosis has been abundantly s...

The case of a 34 year old woman with systemic lupus erythematosus with a history of three previous recurrent abortions and lupus anticoagulant and anticardiolipin antibodies is reported. Immunoadsorbent plasmapheresis with a dextran sulphate column was used to remove lupus anticoagulant, anticardiolipin antibodies, and antibodies to DNA during her fourth pregnancy in combination with low doses ...

The case of a 13 year old girl with renal artery thrombosis and hypertension is described. A cerebrovascular accident and a probable occlusion of the superior mesenteric artery also occurred. Very high levels of 'lupus anticoagulant', anticardiolipin antibodies as well as false positive Venereal Disease Research Laboratory tests were repeatedly shown. Moreover, the patient fulfilled at least fo...

Systemic lupus erythematosus (SLE) can be associated with vascular thrombosis due to antiphospholipid antibodies. Accumulating evidence indicates that renal microvascular thrombosis due to lupus anticoagulant is an independent risk factor for poor renal outcome in lupus nephritis [1, 2]. In this report, we present a young woman with diffuse proliferative lupus nephritis and glomerular microthro...