BACKGROUND Acute lung injury (ALI) is a common and serious complication of severe acute pancreatitis (SAP). The study aimed to investigate the protective effect and mechanism of phosphatidylinositol-3 kinase (PI3K) inhibitor Wortmannin in SAP associated with ALI. METHODS Ninety rats were randomly divided into three groups: sham operation (SO) group (n=30), SAP group (n=30), and SAP+Wortmannin...

The effect of theophylline on colony stimulating factor production by the lung tissue was investigated. Addition of various concentrations of theophylline to the lung conditioned medium enhanced CSF production at 10 µg/ml and at higher concentrations showed an inhibitory effect. Determination of the phosphate content of the medium showed a decrease at 1-3 hours of incubation. Addition of A...

OBJECTIVE This study evaluated the protective antioxidant effect of melatonin on lung injury as a remote organ after skeletal muscle ischemia-reperfusion in rats. METHODS Thirty male Wistar rats were allocated randomly into three experimental groups: operated with no ischemia (Sham) group, ischemia-reperfusion group and ischemia-reperfusion+melatonin group. Hind limb ischemia was induced by c...

After cardiovascular causes, infectious diseases are the next most common cause of death for dialysis patients. The Japanese Society for Dialysis Therapy reported an increased standardized mortality of 7.5-fold [95% confidence limits (CI) 7.3–7.6] for infectious diseases between 2008 and 2009 compared with the general Japanese population. The increased mortality rates for dialysis patients were...

Acute lung injury (ALI), a serious respiratory distress has been associated with considerable human morbidity and mortality. Taurine, a physiological semi-essential amino acid has been shown to be tissue-protective in several models of oxidant-induced injury. Therefore, the current study was designed to explore protective effects of the taurine in ALI mice models. The possible tissue protective...

STUDY OBJECTIVE In order to assess the effects of inhaled nitric oxide (iNO) in preventing early-onset lung edema from occurring after lung transplantation, we measured extravascular lung water (EVLW) in a group of lung transplant recipients who were at high risk for developing ischemia-reperfusion-induced lung injury. DESIGN Prospective, randomized study. SETTINGS Surgical ICU in a teachin...

Recent studies emphasize the presence of alveolar tissue inflammation in asthma. Immunotherapy has been considered a possible therapeutic strategy for asthma, and its effect on lung tissue had not been previously investigated. Measurements of lung tissue resistance and elastance were obtained before and after both ovalbumin and acetylcholine challenges. Using morphometry, we assessed eosinophil...

Pulmonary edema after ascent to altitude is well recognized but its pathogenesis is poorly understood. To determine whether altitude exposure increases lung vascular permeability, we exposed rats to a simulated altitude of approximately 14,500 feet (barometric pressure [Pb] 450 Torr) and measured the pulmonary transvascular escape of radiolabeled 125I-albumin corrected for lung blood content wi...

Background: Hookah smoking has been growing among people because consumers believe that smoking in the form of hookahs has lesser health effects than cigarettes. However, recent reports showed that water pipe smoking (WSP) increased heart rate, blood pressure, impaired pulmonary function and carbon monoxide intoxication. Chronic bronchitis, emphysema and coronary artery disease are serious prob...