Multicenter, randomized, controlled trials and meta-analyses have demonstrated that, during abdominal surgery, protective ventilation, based on low tidal volumes, positive end-expiratory pressure, and recruitment maneuvers improves postoperative outcomes (1). Protective ventilation strategies are aimed at preventing alveolar over-distension, cyclic opening and closure of peripheral airways, tra...

Introduction: Although aluminum oxide nanoparticles (Al2O3-NPs) are the most widely used nanomaterials, limited studies have been reported on their toxicology. Therefore, the present study aimed to investigate the potential toxicity of aluminum oxide (alumina) nanoparticles and the protective role of aqueous extract of wormwood plant on nanomaterial-induced disorders in the lung of rats. Mater...

OBJECTIVE To compare the effects of high-frequency oscillatory ventilation and conventional protective mechanical ventilation associated with the prone position on oxygenation, histology and pulmonary oxidative damage in an experimental model of acute lung injury. METHODS Forty-five rabbits with tracheostomy and vascular access were underwent mechanical ventilation. Acute lung injury was indu...

The lung-protective mechanical ventilation strategy has been standard practice for management of acute respiratory distress syndrome (ARDS) for more than a decade. Observational data, small randomized studies and two recent systematic reviews suggest that lung protective ventilation is both safe and potentially beneficial in patients who do not have ARDS at the onset of mechanical ventilation. ...

Widespread use of herbal drugs because of their protective effects on different organs toxicity has been shown in many studies. These protective effects have been illustrated in the fields of nephrotoxicity, hepatotoxicity, viral hepatitis, cancer, in vitro fertilization, neurotoxicity, depression, lung diseases, prostate diseases etc. Silymarin has cytoprotection activities due to its antioxid...

BACKGROUND In anesthetized patients undergoing surgery, the role of lung-protective ventilation with lower tidal volumes is unclear. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effect of this ventilation strategy on postoperative outcomes. METHODS We searched electronic databases from inception through September 2014. We included RCTs that compared prot...

BACKGROUND Lung-protective ventilation with the use of low tidal volumes and positive end-expiratory pressure is considered best practice in the care of many critically ill patients. However, its role in anesthetized patients undergoing major surgery is not known. METHODS In this multicenter, double-blind, parallel-group trial, we randomly assigned 400 adults at intermediate to high risk of p...

BACKGROUND To study the protective effects and explore the mechanism of epigallocatechingallate (EGCG) on the hip fracture-induced acute lung injury. MATERIAL AND METHODS Thirty male Sprague-Dawley (SD) rats were randomly divided into the control group, hip fracture group, and hip fracture + EGCG (10 mg/Kg) group. After 24 h, blood samples, bronchoalveolar lavage fluid (BALF), and lung tissue w...

background and purpose: many workers are exposed to workplace hazards. many occupational diseases are preventable by personal protective devices (ppds). though many workers do not use ppds or their protection by ppds is not sufficient. this study was designed to assess the quality of ppds usage among industrial workers. materials and methods: in a cross-sectional study, 648 workers from four ma...