Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous inherited disease causing hypopigmentation and prolonged bleeding times. An additional serious clinical problem of HPS is the development of lung pathology, which may lead to severe lung disease and premature death. No cure for the disease exists, and previously, no animal model for the HPS lung abnormalities has been reported. A mo...

The density dependence of maximal expiratory flow is not an effective test of the site of airway narrowing in obstructive lung disease. We hypothesized that the density dependence of pulmonary resistance (DD,RL) would be more closely related to the degree of airway narrowing and peripheral airway pathology in smokers. We measured maximal expiratory flow at 50% vital capacity (V'max50) and lung ...

This study presents an image analysis algorithm for quantifying the volume fraction of pathology in serial histology of the rat lung. The right lung of male Sprague-Dawley rats (n=4) was contused using a controlled insult applied via an instrumented, electronic piston. The right (struck) and left lungs were excised at 48 hours post-insult, fixed in 10% formalin. Serial histology was taken at 1....

A pulmonary hernia is a protrusion of the lung through defect in surrounding tissues, rather rare pathology and each clinical case scientific interest. The first description this was performed by Roland 1499. About 300 observations have been described world literature, most publications are isolated cases observation pathology. We presented experience thoracoscopic hernioplasty Russian Federati...

Pulmonary sequestration is a rare congenital abnormality which often diagnosed in childhood. There are two types of differentiated by the presence, or lack pleural lining dividing aberrant lung tissue from functional lung. Data for management this pathology adults remains scarce. Here we present case intralobar pulmonary an adult. The patient comprised surgical treatment involving lobectomy and...

Pathology of the respiratory system and especially lung pathology has multiple implications in the daily forensic activity and represents a challenging domain of research as well. In the general part of the research work I present the most important data from the literature concerning lung anatomy and histology, elementary lung morphologic lesions, histomorphology of shock lung, physiopathology...

BACKGROUND Histologic and molecular subtyping have become increasingly important as predictors of treatment benefit in lung cancer. The objective of the present study was to determine whether current diagnostic approaches provide adequate tissue to allow for individualized treatment decisions. METHODS Our retrospective cohort study of new lung cancer patients seen at an academic centre betwee...