نتایج جستجو برای: lung mitochondria
تعداد نتایج: 354393 فیلتر نتایج به سال:
in this study the uptake and metabolism of adenosine by mitochondria has been investigated. incubation of cem cells mitochondria preparation with [3h] -adenosine showed substantial uptake and metabolism of adenosine. adenosine was both anabolized to amp, adp and atp, and also catabolized to inosine. the highest concentration of metabolites in extracted mitochondria was due to amp. the mitochond...
he method of morphometric analysis was used to study ultrastructural changes in the mitochondria lungs rats after a single intratracheal injection chrysotile-asbestos dust into animals at doses 25 mg and 50 mg. According parameters, more serious were detected under influence asbestos dose mg, which characterized by significant increase area, perimeter average diameter outer inner membranes. The...
In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mito...
Hyperoxia is known to injure tissues and cells (1) . In a series of papers the quantitative influence of hyperoxia on some aspects of lung ultrastructure was elucidated (2-4) . These studies revealed that hyperoxia resulted in rapid destruction of the pulmonary capillaries, a thickening of the air-blood barrier, and, eventually, a repopulation of the alveolar epithelium by granular pneumocytes ...
BACKGROUND Epithelial cell death is a major contributor to fibrogenesis in the lung. In this study, we sought to determine the function of mitochondria and their clearance (mitophagy) in alveolar epithelial cell death and fibrosis. METHODS We studied markers of mitochondrial injury and the mitophagy marker, PTEN-induced putative kinase 1 (PINK1), in IPF lung tissues by Western blotting, trans...
Hyperoxia is known to injure tissues and cells (1) . In a series of papers the quantitative influence of hyperoxia on some aspects of lung ultrastructure was elucidated (2-4) . These studies revealed that hyperoxia resulted in rapid destruction of the pulmonary capillaries, a thickening of the air-blood barrier, and, eventually, a repopulation of the alveolar epithelium by granular pneumocytes ...
mitochondria are unique organelles with major role in cellular function, not only as a major site of atp production, but also by regulating energy expenditure, apoptosis signaling, and production of reactive oxygen species. they play a central role in determining the point-of-no-return for the apoptotic process. there is accumulating evidence supporting a direct link between mitochondria, oxida...
HYPOTHESIS Fractures and femoral reaming are associated with lung injury. The mechanisms linking fractures and inflammation are unclear, but tissue disruption might release mitochondria. Mitochondria are evolutionarily derived from bacteria and contain "damage associated molecular patterns" like formylated peptides that can activate immunocytes. We therefore studied whether fracture reaming rel...
Pulmonary endothelial cell (EC) apoptosis has been implicated in the pathogenesis of emphysema. Cigarette smoke (CS) causes lung EC apoptosis and emphysema. In this study, we show that CS exposure increased lung tissue adenosine levels in mice, an effect associated with increased lung EC apoptosis and the development of emphysema. Adenosine has a protective effect against apoptosis via adenosin...
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