نتایج جستجو برای: lung mitochondria

تعداد نتایج: 354393  

Journal: :Free Radical Biology and Medicine 2020

Journal: :medical journal of islamic republic of iran 0
a. majid cheraghali from the department of pharmacology and toxicology, faculty of medicine, baghyatollah university of medical sciences, tehran, i.r. iran alan r.p paterson the department of pharmacology, university of alberta, edmonton, alberta, canada. wendy p. gati the department of pharmacology, university of alberta, edmonton, alberta, canada.

in this study the uptake and metabolism of adenosine by mitochondria has been investigated. incubation of cem cells mitochondria preparation with [3h] -adenosine showed substantial uptake and metabolism of adenosine. adenosine was both anabolized to amp, adp and atp, and also catabolized to inosine. the highest concentration of metabolites in extracted mitochondria was due to amp. the mitochond...

Journal: : 2023

he method of morphometric analysis was used to study ultrastructural changes in the mitochondria lungs rats after a single intratracheal injection chrysotile-asbestos dust into animals at doses 25 mg and 50 mg. According parameters, more serious were detected under influence asbestos dose mg, which characterized by significant increase area, perimeter average diameter outer inner membranes. The...

A. MAJID CHERAGHALI, ALAN R.P PATERSON, WENDY P. GATI,

In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mito...

Journal: :The Journal of Cell Biology 1973
Gloria D. Massaro Donald Massaro

Hyperoxia is known to injure tissues and cells (1) . In a series of papers the quantitative influence of hyperoxia on some aspects of lung ultrastructure was elucidated (2-4) . These studies revealed that hyperoxia resulted in rapid destruction of the pulmonary capillaries, a thickening of the air-blood barrier, and, eventually, a repopulation of the alveolar epithelium by granular pneumocytes ...

2015
Avignat S. Patel Jin Woo Song Sarah G. Chu Kenji Mizumura Juan C. Osorio Ying Shi Souheil El-Chemaly Chun Geun Lee Ivan O. Rosas Jack A. Elias Augustine M. K. Choi Danielle Morse

BACKGROUND Epithelial cell death is a major contributor to fibrogenesis in the lung. In this study, we sought to determine the function of mitochondria and their clearance (mitophagy) in alveolar epithelial cell death and fibrosis. METHODS We studied markers of mitochondrial injury and the mitophagy marker, PTEN-induced putative kinase 1 (PINK1), in IPF lung tissues by Western blotting, trans...

2003
GLORIA D. MASSARO

Hyperoxia is known to injure tissues and cells (1) . In a series of papers the quantitative influence of hyperoxia on some aspects of lung ultrastructure was elucidated (2-4) . These studies revealed that hyperoxia resulted in rapid destruction of the pulmonary capillaries, a thickening of the air-blood barrier, and, eventually, a repopulation of the alveolar epithelium by granular pneumocytes ...

Journal: :the iranian journal of pharmaceutical research 0
jalal pourahmad department of pharmacology and toxicology, school of pharmacy, shahid beheshti university of medical sciences tehran, iran. mir jamal hosseini department of pharmacology and toxicology, school of pharmacy zanjan university of medical sciences zanjan, iran.

mitochondria are unique organelles with major role in cellular function, not only as a major site of atp production, but also by regulating energy expenditure, apoptosis signaling, and production of reactive oxygen species. they play a central role in determining the point-of-no-return for the apoptotic process. there is accumulating evidence supporting a direct link between mitochondria, oxida...

Journal: :Journal of orthopaedic trauma 2010
Carl J Hauser Tolga Sursal Edward K Rodriguez Paul T Appleton Qin Zhang Kiyoshi Itagaki

HYPOTHESIS Fractures and femoral reaming are associated with lung injury. The mechanisms linking fractures and inflammation are unclear, but tissue disruption might release mitochondria. Mitochondria are evolutionarily derived from bacteria and contain "damage associated molecular patterns" like formylated peptides that can activate immunocytes. We therefore studied whether fracture reaming rel...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2013
Qing Lu Pavlo Sakhatskyy Julie Newton Paul Shamirian Vivian Hsiao Sean Curren Gustavo Andres Gabino Miranda Mesias Pedroza Michael R Blackburn Sharon Rounds

Pulmonary endothelial cell (EC) apoptosis has been implicated in the pathogenesis of emphysema. Cigarette smoke (CS) causes lung EC apoptosis and emphysema. In this study, we show that CS exposure increased lung tissue adenosine levels in mice, an effect associated with increased lung EC apoptosis and the development of emphysema. Adenosine has a protective effect against apoptosis via adenosin...

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