Phosphatidylinosital-4,5-bisphosphate (PIP 2 ) acts as an essential factor regulating the activity of all Kir channels. In most Kir members, the dependence on PIP 2 is modulated by other factors, such as protein kinases (in Kir1), G (in Kir3), and the sulfonylurea receptor (in Kir6). So far, however, no regulator has been identified in Kir2 channels. Here we show that polyamines, which cause in...

Phosphatidylinosital-4,5-bisphosphate (PIP2) acts as an essential factor regulating the activity of all Kir channels. In most Kir members, the dependence on PIP2 is modulated by other factors, such as protein kinases (in Kir1), G(betagamma) (in Kir3), and the sulfonylurea receptor (in Kir6). So far, however, no regulator has been identified in Kir2 channels. Here we show that polyamines, which ...

Asthma is a complex disease of airways, where the interactions of immune and structural cells result in disease outcomes with airway remodeling and airway hyper-responsiveness. Polyamines, which are small-sized, natural super-cations, interact with negatively charged intracellular macromolecules, and altered levels of polyamines and their interactions have been associated with different patholo...

Polyamines are unique polycationic metabolites, controlling a variety of vital functions in plants, including growth and stress responses. Over the last two decades a bulk of data was accumulated providing explicit evidence that polyamines play an essential role in regulating plant membrane transport. The most straightforward example is a blockage of the two major vacuolar cation channels, name...

background: the etiology of breast cancer and our understanding on the carcinogenicity of different risk factors is impotant for control programms. objective: we investigated the expression of estrogen and progesterone receptors (er, pr), and human epithelial receptor 2 (her2) overexpression and its associations, with environmental risk factors among breast cancer patients.  methods: we classif...

It was previously reported that bacteriophage T4 contains the polyamines putrescine, NH2(CH2)$;IH2, and spermidine, NHQ(CH&NH(CH&NH2, in amounts sufficient to neutralize about half of the viral deoxyribonucleic acid (1). The putrescine and spermidine in the phage were found to be derived from the large amount of these polyamines normally present in the host bacterium, Escherichia coli B. It was...

central venous catheterization (cvc) is a commonly performed procedure for venous access. it is associated with several complications. we report a rare case of extra luminal entrapment of guide wire during cvc placement in right jugular vein. we report a case of 28 years old female patient presented in our emergency with history of entrapped guide wire in right side of neck during cvc. x-ray sh...

The naturally occurring polyamines putrescine, spermidine, and spermine are involved in signal transduction. This has been demonstrated by using inhibitors for polyamine biosynthesis (such as alpha-difluoromethylornithine) or adding polyamines to cultured cells. Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclea...

The incorporation of l-[(14)C]ornithine and [(14)C]putrescine into putrescine, spermidine, and spermine in type 5 adenovirus-infected KB cells was identical to that in uninfected control cells early in infection, but incorporation into putrescine stopped after 8 to 12 h and the rate of incorporation into spermidine was reduced between 12 and 20 h after infection. The amount of polyamines found ...